1. Figure Legend: From: Noncoding RNAs:New Players in Chronic Pain
Anesthes. 2014;121(2): doi: /ALN
Figure Legend:
Proposed model for the mechanism of how Kcna2 AS RNA is involved in neuropathic pain. Nerve injury leads to an increase in myeloid zinc finger gene 1 (MZF1), a transcription factor that enhances the transcription of Kcna2 AS RNA, in dorsal root ganglion (DRG). The Kcan2 AS RNA silences expression of the Kcna2 messenger RNA (mRNA) and protein. The reduced Kcna2 protein expression at DRG neuronal membrane results in reduced K+ current (Kv), increases number of action potentials (AP) and neuronal excitability in DRG neurons, and produces spinal cord central sensitization and neuropathic pain symptoms (hyperalgesia and allodynia).
Date of download: 10/27/2017
Copyright © 2017 American Society of Anesthesiologists. All rights reserved.