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Pharmaceutical Particles
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Taylor Cone When a sufficiently high voltage is applied to a liquid droplet, the body of the liquid becomes charged, and electrostatic repulsion counteracts the surface tension and the droplet is stretched; at a critical point a stream of liquid erupts from the surface. This point of eruption is known as the Taylor cone. Taylor cone Jet Fibers
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Electro-hydrodynamic Atomization Process (Hydrospraying)
Using electric field to break liquid drops into fine droplets Vn Vr Vacuum pump Filter Particles : the trace of protective Nitrogen; : solvent with polymer & drugs; : volatilized solvent; : collected polymer & drug particles; Vn : high voltage used to break liquid drops; Vr : high voltage applied to metal hoop;
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Electrospinning https://www.youtube.com/watch?v=87uRQ7KwbB0
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Supercritical AntiSolvent setup
TC PI V2 V1 V3 F2 F1 C2 CO2 C1
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U1 P1 P2 TC PI V2 V1 V3 F2 F1 C2 CO2 C1
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Conclusion Different methods of producing drugs (particles)
How particle sizes are controlled in each production method Gam-Sia-Hamida
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