1. Trained Linear Regression between TF  TG

2. RNA Expression Noise Distribution

3. TFTG Upstream centric analyses

6. Checking Sample Bias

7. Checking Degree Bias

8. Coefficient comparison

9. Top 10% differentially regulated TSG – Drug Enrichment
nystatin 2
8797 7048
C=4;O=2;E=0.40;R=5.01;rawP=0.0516;adjP=0.2781
carboplatin
2950 10769
C=3;O=2;E=0.30;R=6.68;rawP=0.0276;adjP=0.2781
inulin
5581 23513
ifosfamide
2950 2719

10. Top 10% differentially regulated ONG – Drug Enrichment
#Gene
EntrezGene
Statistics
fluorouracil 3
673 1956 4436
C=9;O=3;E=0.89;R=3.35;rawP=0.0496;adjP=0.2091
carbachol 2
387 1956
C=4;O=2;E=0.40;R=5.03;rawP=0.0506;adjP=0.2091

11. Top 10% differentially regulated TSG – Pathways
PathwayName
#Gene
EntrezGene
Statistics
Urea cycle and metabolism of amino groups 2
445 95
C=2;O=2;E=0.20;R=10.03;rawP=0.0098;adjP=0.1176
Striated Muscle Contraction
7431 1756

12. Top 10% differentially regulated ONG – Pathways
PathwayName
#Gene
EntrezGene
Statistics
Serotonin HTR1 Group and FOS Pathway 3
673 387 5604
C=6;O=3;E=0.60;R=5.03;rawP=0.0146;adjP=0.1947
Regulation of Actin Cytoskeleton 6
673 387 22800 1956 
C=21;O=6;E=2.09;R=2.88;rawP=0.0110;adjP=0.1947
Pathogenic Escherichia coli infection
387 2534 999
IL-7 signaling pathway 4
2534 3716 3718 5604
C=13;O=4;E=1.29;R=3.10;rawP=0.0304;adjP=0.3040
Serotonin Receptor and NR3C Signaling 2
673 5604
C=4;O=2;E=0.40;R=5.03;rawP=0.0506;adjP=0.4048
Syndecan-3-mediated signaling events 2
2534 1956
C=3;O=2;E=0.30;R=6.71;rawP=0.0270;adjP=0.6645
L1CAM interactions 3
387 1956 5604
C=7;O=3;E=0.70;R=4.31;rawP=0.0238;adjP=0.6645
E-cadherin signaling in keratinocytes 4
387 2534 999 1956
C=13;O=4;E=1.29;R=3.10;rawP=0.0304;adjP=0.6645

13. Top 10% differentially regulated TSG – KEGG Pathways
PathwayName
#Gene
EntrezGene
Statistics
Natural killer cell mediated cytotoxicity 3
8797 6850 5777
C=8;O=3;E=0.80;R=3.76;rawP=0.0370;adjP=0.2270
Adherens junction
5795 7048 5777
C=7;O=3;E=0.70;R=4.30;rawP=0.0249;adjP=0.2270
Arrhythmogenic right ventricular cardiomyopathy (ARVC) 4
1756 3728 
C=11;O=4;E=1.10;R=3.65;rawP=0.0175;adjP=0.2270
Arginine and proline metabolism 2
445 95
C=4;O=2;E=0.40;R=5.01;rawP=0.0516;adjP=0.2270
Dilated cardiomyopathy
1756 3679 3690
C=9;O=3;E=0.90;R=3.34;rawP=0.0516;adjP=0.2270

14. Top 10% differentially regulated ONG – KEGG Pathways
PathwayName
#Gene
EntrezGene
Statistics
Pathogenic Escherichia coli infection 3
2534 387 999
C=6;O=3;E=0.60;R=5.03;rawP=0.0146;adjP=0.3307
Adherens junction 5
4301 2534 387 999 1956
C=18;O=5;E=1.79;R=2.80;rawP=0.0237;adjP=0.3307
Oocyte meiosis 2
5518 5604
C=3;O=2;E=0.30;R=6.71;rawP=0.0270;adjP=0.3307
Regulation of actin cytoskeleton 6
387 673 22800 5159 
C=25;O=6;E=2.48;R=2.42;rawP=0.0267;adjP=0.3307

15. Top 10% differentially regulated TSG – Disease
#Gene
EntrezGene
Statistics
Fasciculation 2
10277 2048
C=2;O=2;E=0.20;R=10.03;rawP=0.0098;adjP=0.2954
Muscular Dystrophies 3
79026 1756 3679
C=5;O=3;E=0.50;R=6.02;rawP=0.0082;adjP=0.2954
Thyroid Nodule
3880 678
Gastroesophageal Reflux
3728 2950
liver transplantation 4
445 23705 10397 2719
C=7;O=4;E=0.70;R=5.73;rawP=0.0025;adjP=0.2954
Arsenic Poisoning
847 2950
heparin-induced thrombocytopenia
5795 3690

16. Top 10% differentially regulated ONG – Disease
#Gene
EntrezGene
Statistics
Carcinoma, Acinar Cell 3
4221 999 1956
C=8;O=3;E=0.80;R=3.77;rawP=0.0355;adjP=0.5358
Vulvar Diseases 2
999 1956
C=4;O=2;E=0.40;R=5.03;rawP=0.0506;adjP=0.5358
Alzheimer Disease
2534 8301
C=2;O=2;E=0.20;R=10.06;rawP=0.0096;adjP=0.5358