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Do patients with the heparin-induced thrombocytopenia syndrome have heparin-specific antibodies?  John G. Adams, MD, Loren J. Humphrey, MD, PhD, Xinchao.

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Presentation on theme: "Do patients with the heparin-induced thrombocytopenia syndrome have heparin-specific antibodies?  John G. Adams, MD, Loren J. Humphrey, MD, PhD, Xinchao."— Presentation transcript:

1 Do patients with the heparin-induced thrombocytopenia syndrome have heparin-specific antibodies? 
John G. Adams, MD, Loren J. Humphrey, MD, PhD, Xinchao Zhang, MD, Donald Silver, MD  Journal of Vascular Surgery  Volume 21, Issue 2, Pages (February 1995) DOI: /S (95) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

2 Fig. 1 Demonstration of 50kd bands produced in SDS-PAGE by IgG+ plasmas 1 through 7 after immunoprecipitation after heparin exposure. IgG+ 6 did not stain as heavily as other plasmas, but 50 kd band can be identified. Identity of bands was confirmed by fluorescent-labeled anti-IgG reagents. (STD represents purified standard proteins (14.4 kd to 97.4 kd), BIO-RAD; 1-7 represent IgG+ plasmas 1 through 7). Journal of Vascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

3 Fig. 2 Example of 25 kd band (black arrow represents F(ab′)2 fragments) produced in SDS-PAGE after immunoprecipitation after heparin exposure of isolated F(ab′)2 fragments of HAb+ plasma sample 1. Identity of the bands was confirmed by fluorescent-labeled anti-IgG reagents. (1 represents purified standard proteins (14.4 kd to 66.2 kd), BIO-RAD; 2 represents isolated F(ab′)2 fragment of HAb+ plasma sample 1; 3 represents HAb– plasma; 4 represents IgG+ plasma 1). Journal of Vascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

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