1. First European Workshop on Ataxia-Telangiectasia Clinical Science for A-T: Status Quo and Future Directions Dear Colleagues, we have the pleasure to invite you to the First European Workshop on Ataxia- Telangiectasia in Frankfurt, Germany. We now have further information about the venue and hotel. Please contact our university office for Registration and Abstract Submission. Registration for the workshop is free. Abstract Submission will be open until 1 st December 2010. Thank you very much Looking forward to welcoming you in Frankfurt in January 2011 Stefan Zielen & Ralf Schubert Office Brigitte Kraft Klinikum der J.W. Goethe Universität Klinik für Kinder- und Jugendmedizin Theodor-Stern-Kai 7 60590 Frankfurt am Main Phone: +49-69-6301-83063 Fax: +49-69-6301-83349 Email: Brigitte.Kraft@kgu.deBrigitte.Kraft@kgu.de Frankfurt, Germany 28.01. and 29.01.2011

2. Venue/Hotel The Workshop will be held at the Innside Hotel Frankfurt Niederrad. Rooms have been reserved for workshop participants at special conference rates (99 /night). All participants will be responsible for arranging their own travel and hotel reservations. When booking your room, please use the keyword AT-Workshop. Innside Hotel Frankfurt Niederrad Herriotstrasse 2, 60528, Frankfurt am Main Phone: +49 69 67732-0 FAX: +49 69 67732-222 Email: frankfurt.niederrad@innside.defrankfurt.niederrad@innside.de Abstract Submission All abstract submissions are subject to review by the scientific committee. For (poster) presentations, authors will present ideas relating to the conference theme Clinical Science for A-T and one of the conference topics listed below. Topics: Neurological Abnormalities Pneumological Disease Cancer Predisposition Immunodeficiency A-T Registery All abstracts must be submitted in English. The submitted abstract should be limited to a maximum of 400 words excluding the title, authors and institutions. A special support on the hotel rate (20 %) will be provided for all investigators selected for oral or poster presentations. General Information

3. Program 12.00 - 13.00Lunch - Come together 13.00 - 13.15Opening - Stefan Zielen & Ralf Schubert 13.15 - 14.00 Clinical science I Plenary Session - Richard Gatti 14.00 - 15.30 Neurology Workgroup 14.00 - 15.30 Lung Disease Workgroup 14.00 - 15.30 Immunodeficiency and Laboratory Evaluation Workgroup 14.00 - 15.30 Biologics: Cancer and ATM Function Workgroup 15.30 - 16.00Coffee Break 16.00 - 17.30 Therapeutic Approaches Pre-Clinical Trials Free Presentations 17.30 - 18.30Poster Session 19.00 -Dinner and Social Event Friday 28.01.2011 Saturday 29.01.2011 08.15 -9.00 Clinical science II Plenary Session - N.N. 09.00 - 10.30 Therapeutic Approaches II Clinical Trials Free Presentations 10.30 - 11.00Coffee Break 11.00 - 12.30 Workshop Reports Neurology Lung Disease Immunodeficiency and Lab Evaluation Biologics: Cancer and ATM Function

4. 12.30 - 13.30Lunch Break 13.30 - 14.30Poster Session 14.30 - 15.30 ESID Report A-T Registery Plenary Session N.N. 15.30 - 16.00Coffee Break 16.00 - 17.00 Future European Studies and Applications Diskussion End of Meeting Program Saturday 29.01.2011