1. Mitochondrial Ferritin Protects Hydrogen Peroxide-Induced Neuronal Cell Damage
Guofen Gao 1 ;Nan Zhang 1 ;Yue-Qi Wang 1 ;Qiong Wu 1 ;Peng Yu 1 ;Zhen-Hua Shi 1 ;Xiang-Lin Duan 1 ;Bao-Lu Zhao 1 ;Wen-Shuang Wu 2 ;Chang Yan-Zhong 1 ;
1 Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, Hebei, , China ; 2 The 3rd Hospital of Hebei Medical University, Shijiazhuang, Hebei, , China ;
Figure 6. FtMt repressed the alterations of iron release and uptake proteins induced by H 2 O 2 treatment 100 #cod#x003BC;M, 24 h FPN1 A , TfR1 B , DMT1+IRE C , DMT1-IRE D , L-ferritin E and H-ferritin F levels were determined by western blots. A representative blot image for each protein and its respective #cod#x003B2;-actin was shown. The expression levels in different groups were calculated by normalizing the specific bands to their respective #cod#x003B2;-actin bands. The relative expression levels as compared to WT untreated control group were calculated and presented as means #cod#x000B1; SD, n=6 #cod#x0002A;, p #cod#x0003C;0.05 vs. the untreated cells of same genotype; #cod#x00026;, p #cod#x0003C; 0.05 vs. the untreated vector controls; #, p #cod#x0003C; 0.05 and ##, p #cod#x0003C; 0.01 vs. the H 2 O 2 -treated vector controls.
Aging and Disease,null,8(4), Doi: /AD