1. CORAL
Trial design: Patients with renal artery stenosis and hypertension or chronic kidney disease were randomized to renal artery stenting (n = 467) vs. medical therapy (n = 480).
(p = 0.58)
Results
Death from CV or renal causes, MI, stroke, hospitalization for HF, progressive renal insufficiency, or dialysis: 35.1% of the stent group vs. 35.8% of the medical group (p = 0.58)
Results were similar among prespecified subgroups, including lesion severity, pressure gradient, or baseline blood pressure
35.8
35.1 %
Conclusions
Among patients with renal artery stenosis (with hypertension or renal insufficiency), renal artery stenting was not beneficial
Findings were similar in multiple prespecified subgroups
Renal stenting
Medical therapy
Cooper CJ, et al. N Engl J Med 2014;370:13-22