1. Lactase genes and evolution

2. Points of concern Lactase and curriculum What is the problem?
General Biology course
General Microbiology
Genetics
What is the problem?
Students misconceptions

3. Data set 86

4. resources
See images.ppt and .doc files for visual database of organisms from which sequences were obtained
Sequence files (.doc) are organized by type of organism and lactase subunit

5. Sample Questions: Level 1
Is the bacterial lactase gene similar to the human lactase gene?
Is this gene exclusive to eukaryotic or to prokaryotic organisms?
How is this gene distributed across the organisms?

6. Sample Questions: Level 2
How does the bacterial lactase gene compare to archaebacteria?
What evolution scheme can be inferred?
Describe the evolutionary relationships within and among the different groups of organisms.

7. Plant data

8. Unrooted tree for plant data

9. Splt Decomposition (ESTEEM module) to determine relationships between four plants based on lactase sequence

14. References Genoscope Centre national de séquençage
BRENDA: The Comprehensive Enzyme Information System
Genomics: GLT, Systems Biology for Energy and Environment
Genomes News Network
Doe Joint Genome Institute
Fungal Cell Biology Group BaNG: Nematodes and Neglected Genomics
iHOP- Information Hyperlinked over proteins
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI)
National Center for Biotechnology Information
Biology Workbench