1. Wake-up
A woman carrying colorblindness marries a normal male. What are the chances of producing a colorblind child?
Cross a man with AB blood with a woman that is heterozygous A. What blood types will their kids have?
Explain how you are genetic mixture of your parents. (THINK)

2. XB Y XBXb x XBY XB XBY Xb XbY XBXB XBXb Wake-up #1
A woman carrying colorblindness marries a normal male. What are the chances of producing a colorblind child? XB Y
XBXb x XBY XB
XBXB
XBY
25% chance Xb
XbY
XBXb

3. IA i IAIB x IAi IA IAi IB IBi IAIA IAIB Wake-up #2
Cross a man with AB blood with a woman that is heterozygous A. What blood types will their kids have? IA i
IAIB x IAi IA
IAIA
IAi
A, AB, B IB
IBi
IAIB

4. Human Genetic Disorders and Pedigrees
Christopherson

5. Diagram showing a family tree and patterns of inheritance.
What is a Pedigree???
Diagram showing a family tree and patterns of inheritance.

7. 1. Recessive – two recessive alleles 3. Dominant – one dominant allele
Three Modes of
1. Recessive – two recessive alleles
2. Sex-linked (recessive) – recessive alleles linked (attached) to sex chromosomes
3. Dominant – one dominant allele

8. Recessive Trait or Disorder
Traits or disorders caused by 2 recessive alleles

9. Ability to fold tongue like a taco.
Tongue Rolling
Ability to fold tongue like a taco.

10. How does it happen? Ability to Roll Genotype: rr

11. Cystic Fibrosis
Disease that causes the body to produce unusually thick, sticky mucus that:
Clogs the lungs and leads to lung infections
Obstructs the pancreas
Stops natural enzymes from helping the body break down and absorb food

13. How does it happen? (Stop 1:45) Affected Genotype: cc

14. Types of Pedigrees: Recessive
Present/Affected Genotypes: bb
Absent/Unaffected Genotypes: BB or Bb

15. 1. Trait tends to skip generations Generation II was skipped
Rules of Inheritance
1. Trait tends to skip generations
Generation II was skipped

16. Rules of Inheritance
Parents II-1 and II-2 are unaffected, but son (III-2) is affected
1. Affected offspring are usually born from unaffected parents

17. 3. Appears in both sexes equally (not always perfectly equal)
Rules of Inheritance
3. Appears in both sexes equally (not always perfectly equal)

18. Genotypes in Pedigrees
Shaded in shapes are affected or have the recessive trait (add to pedigree in notes) bb bb bb bb bb bb

19. Genotypes in Pedigrees
Blank shapes are BB or Bb (unaffected). You have to figure it out. Remember, you get one allele from each parent. (add to notes) Bb bb Bb Bb Bb Bb bb bb bb bb bb

20. Sex-Linked Trait/Disorder
Traits/disorders linked to sex chromosomes

21. Color of the fur is black, brown, ad orange
Tortoise shelled Cats
Color of the fur is black, brown, ad orange

22. How does it happen? -Tortoise shelled Cats: XBXb (only females) -Sex-linked and Codominant

23. Inability to see colors in the normal way
Color Blindness
Inability to see colors in the normal way

24. Inability of the blood to clot properly
Hemophilia
Inability of the blood to clot properly

25. How does it happen? Affected Genotypes: XhXh XhY

26. Types of Pedigrees: Sex-linked
Present/Affected Genotypes:
XbXb or XbY
Absent/Unaffected Genotypes:
XBXB or XBXb and XBY

27. 1. Mainly males are affected
Rules of Inheritance
1. Mainly males are affected

28. Genotypes in Pedigrees
Shaded in shapes are affected or have the sex-linked trait (add to pedigree in notes)
XbY
XbY
XbY bb bb
XbY
XbY

29. Genotypes in Pedigrees
Blank shapes are XBXB/XBXb or XBY (unaffected). You have to figure it out. Remember, you get one allele from each parent. (add to notes)
XBXb
XBY
XbY
XbY
XBY
XBXb
XbY bb
XBY
XBXb
XBY
XBY
XBY bb
XBY
XbY
XbY

30. Dominant Trait or Disorder
Traits or disorders caused by a dominant allele
Affected individuals are homozygous dominant or heterozygous

31. Earlobes are unattached to head.
Free Earlobes
Earlobes are unattached to head.

32. How does it happen? Free Earlobes: FF or Ff

33. Huntington’s Disease
Causes the break down of brain cells, (neurons) in certain areas of the brain.
Causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance.

34. Normal Brain
Cross section
Huntington’s Brain
Cross section

35. How does it happen? Affected Genotype: HH or Hh

36. Types of Pedigrees: Dominant
Affected Genotypes: BB or Bb
Unaffected Genotypes: bb

37. Rules of Inheritance
1. At least one parent has to be affected with the trait in order to have affected child.

38. 2. Appears in both sexes equally
Rules of Inheritance
2. Appears in both sexes equally

39. Genotypes in Pedigrees
Blank shapes are bb (unaffected) in a Dominant Pedigree. bb bb bb bb bb bb bb bb

40. Genotypes in Pedigrees
Shaded in shapes are affected or have the dominant trait. They are BB or Bb. You have to figure it out. (add to pedigree in notes) bb Bb Bb bb bb Bb bb Bb bb bb Bb Bb Bb bb Bb bb

41. Let’s practice identifying the mode of inheritance.
Identify each of the following pedigrees as Recessive, Dominant, or Sex-linked. Use the Rules from your notes.

42. What type of inheritance?

43. Sex-linked

44. What type of inheritance?

45. Dominant

46. What type of inheritance?

47. Recessive

48. What type of inheritance?

49. Sex-linked

50. What type of inheritance?

51. Dominant

52. What type of inheritance?
Be careful!!! A ½ shaded square or circle means that they are a CARRIER; that means they do not have the trait.

53. Sex-linked

54. What type of Inheritance?

55. Recessive

56. Pedigree Tutorial
The video has no sound, but it is GREAT!! Watch it to help understanding.

57. When complete with the notes, get the Pedigree Analysis and Nicotine Article from the substitute.
Select the “Activity LINK” for today on the Wiki. You will need headphones for this.
This activity is pretty fun. You need to listen to the various interviews and fill out a pedigree for a family. You are researching the inheritance of the addiction gene.