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Effect of Renin-Angiotensin System Blockade on Calcium Channel Blocker-Associated Peripheral Edema  Harikrishna Makani, MD, Sripal Bangalore, MD, MHA,

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Presentation on theme: "Effect of Renin-Angiotensin System Blockade on Calcium Channel Blocker-Associated Peripheral Edema  Harikrishna Makani, MD, Sripal Bangalore, MD, MHA,"— Presentation transcript:

1 Effect of Renin-Angiotensin System Blockade on Calcium Channel Blocker-Associated Peripheral Edema 
Harikrishna Makani, MD, Sripal Bangalore, MD, MHA, Jorge Romero, MD, Omar Wever-Pinzon, MD, Franz H. Messerli, MD  The American Journal of Medicine  Volume 124, Issue 2, Pages (February 2011) DOI: /j.amjmed Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 Selection of studies. ACE=ACE inhibitor; ARB=ARB; CCB=calcium channel blocker; RAS=renin-angiotensin system. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © 2011 Elsevier Inc. Terms and Conditions

3 Figure 2 Head-to-head comparison of calcium channel blocker with calcium channel blocker/renin-angiotensin-receptor blocker combination on the incidence of peripheral edema. ACEI = ACE inhibitor; CCB = calcium channel blocker; CI = confidence interval; RAS = renin-angiotensin system. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © 2011 Elsevier Inc. Terms and Conditions

4 Figure 3 Pooled incidence of peripheral edema and withdrawal due to edema with calcium channel blocker and calcium channel blocker/renin-angiotensin-receptor blocker combination. *P < .05 comparing calcium channel blocker with calcium channel blocker/renin-angiotensin-receptor combination. CCB = calcium channel blocker; RAS = renin-angiotensin system. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © 2011 Elsevier Inc. Terms and Conditions

5 Figure 4 Head-to-head comparison of calcium channel blocker with calcium channel blocker/renin-angiotensin-receptor blocker combination on the withdrawal due to peripheral edema. ACEI = ACE inhibitor; CCB = calcium channel blocker; CI = confidence interval; RAS = renin-angiotensin system. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © 2011 Elsevier Inc. Terms and Conditions

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