1. West of England Genomic Medicine Centre
Update for Breast Site Specific Group
Catherine Carpenter-Clawson, Programme Manager

2. Contents Quick Reminder: What? Why? Who? Where? And finally:
How will we do it?
How are we doing?

3. What?
Slide courtesy of NHS England

4. What are the aims - 100,000 Genomes project and genomic medicine
Initiative to perform Whole Genome Sequencing on 100,000 samples from English NHS patients
Make ‘genomic medicine’ part of standard care
Diagnosis
Prognosis
Personalised treatment

5. What do we need to do - genome samples

6. Why?

7. Who are Genomics England?
Genomics England is a wholly owned company of the Department of Health.
Genomics England was set up to deliver the 100,000 Genomes Project by:
Creating Genomic Medicine Centres
Commissioning/working with a company Illumina to sequence 100,000 genomes
Setting up Genomics England Clinical Interpretation Partnerships (GECIPs) to lead the clinical analysis

8. Who is a Genomic Medicine Centre?
A group of NHS providers (and other key local organisations) who have come together to support delivery of the 100,000 Genomes Project
We are ordinary NHS staff seconded to work on the project and set it up alongside existing clinical practice
We are not building a big new centre or working outside of existing NHS structures

9. Where are the Genomic Medicine Centres
NHS Genomic Medicine Centres (NHS GMCs) : mapped against AHSN boundaries
NHS GMCs work in partnership with academia, patients and industry through the AHSNs 

10. How? 100,000 Genomes Project announced 4 years ago – since then established pathways and infrastructure to support genome sequencing
Genomic England is set up to establish sequencing centre and pathways
All 13 centres actively consenting patients to the project
First 11 Genomic Medicine Centres announced
Final 2 Genomic Medicine Centres established
100,000 Genomes Project is launched
Dec 2012
Dec 2013
Dec 2014
Dec 2015
Dec 2016

11. How? First RD samples 10th Jun Designation as GMC 23rd Dec
Go-live Cancer and RD 27th May
First cancer consent
27th Jun
Launch event 26th Sep
Jan 16
Jan 17
Q1 review 22nd Jul
Q2 review 24nd Nov

12. Specimen transport team
Proposed pathway
Pathology
GPs
Imaging
Consultants
Nursing staff
Specialists
Breast Care
Research team
Theatre team
Clinic management
MDT co-ordinators
Specimen transport team
IT experts
How do you develop a pathway? – the key is engagement at every step of the pathway…..
Tumour laboratory
Blood laboratory
Managers
Reception
Processing

13. Cancer roll out programme
How we doing?
Cancer roll out programme
First Glos breast cancer patient consented
Dry run for breast cancer in RUH
North Bristol brain and colorectal patients consented
Planned expansion to Colorectal in Glos underway
Exploration of Haem Onc pathway options progressing

14. Cancer sample breakdown by pathway
WE GMC Quarterly Review - 24/11/2016

15. Cancer trajectory to 26th Jan 2017

16. Deep dive of breast cancer pilot
North Bristol Breast MDT pilot 6 weeks from 29th September

18. Genomics champions – to support education
Name
Main role
Organisation
James Bristol
Consultant cancer surgeon
Glos hospitals
Giles Atton
Foundation Doctor Year 2
NBT
Sadaf Haque
GP Macmillan and Cancer Lead
Glos CCG
Ellen Brennan-Rist
Pharmacist
Bath
Anna Le Fevre
Clinical genetics visiting fellow
Bath & UHB
Diane Barlow
Childrens’ cardiac nurse specialist
UHB
Suriya Kirkpatrick
Senior cancer clinical trials research nurse

19. Patient Public involvement – to promote patient collaboration
National PPI consultation- consent materials, feedback on poster
Contributed resources to national PPI group- PPI Toolkit, public contributor selection materials

20. Communications Information stand roadshows at Trusts Launch Event
Press release to media
Actively updated WEGMC website
WEGMC news in stakeholder newsletters
Clinical engagement and training

21. Informatics – to manage the complex data
1. Data extraction from Starlims system
Operational errors now resolved, DNA sample transfer resumed
Longer term strategy to improve longterm robustness
2. Longterm ‘Connecting Care’ solution for data submission
Delayed introduced by external provider
Intensive catch-up with launch date confirmed 8th December
3. Active programme of electronic input of HPO terms for RD and cancer register data
Informatics lead appointed Aug16
Regional Informatics group established and active

22. Workforce Development – to support current & future staff
‘Box-Ed’ targeted engagement progressed to pilot stage
@Bristol plans to develop community engagement package
Targeted training packages in development
Informatics
Consenting
Training needs analysis disseminated

23. Laboratory – to develop sample processing
Samples exported to biorepository
Logistic pathways for Glos LDP transport tested
Fresh Frozen Pathway for Breast, Brain & Colorectal cancer live at North Bristol Trust
Saturday working underway to facilitate clinics