1. BME 130 – Genomes
Lecture 1
History of Genomics

2. Course policies Grading Group (paper presentations; class assignments)
Course overview
website?

3. Charles Darwin
On the Origin of Species
1859
Gregor Mendel
Experiments in Plant
Hybridisation
1866

4. Statistical genetics, law of ancestral heridity (basis of eugenics)
Francis Galton
Statistical genetics, law of
ancestral heridity (basis of
eugenics)
1876
Propose that hereditary factors reside on chromosomes and are inherited by Mendellian laws (1902)
Walter
Sutton
Theodor
Boveri

5. Archibald Garrod
Alkaptonuria is not caused by bacterial infection, but is inherited (recessive), 1908
Thoman Hunt Morgan
Experimental validation of chromosomal theory of inheritance, established fruit fly as model genetic organism, 1910

6. Crick enunciates central dogma of molecular biology 1957
James Watson and Francis Crick describe a model for the structure of DNA, 1953;
Crick enunciates central dogma of molecular biology 1957

7. Marshall Nirenberg
Cracks the genetic code by translating (first) poly-U, 1961

8. Paul Berg
Creates first recombinant DNA molecules, 1972

9. Herber Boyer and Stan Cohen
Clone DNA into foreign cells; birth of recombinant DNA technology, 1973

10. Walter Gilbert and Fred Sanger
Develop methods to sequence DNA, 1977

11. Kary Mullis
Invents the polymerase-chain reaction for DNA amplification, 1983

12. Scheibye-Alsing et al. (2009),
Comp. Biology & Chemistry 33(2):121

13. Genomes! 1995 Hemophilus influenzae 1996 yeast 1998 worm
1999 fruit fly
2001 human
2002 mouse
2004 rat