1. From: Modeling Keratoconus Using Induced Pluripotent Stem Cells
Invest. Ophthalmol. Vis. Sci ;57(8): doi: /iovs
Figure Legend:
Proliferation of differentiated keratocytes. (A, C, E) Three normal corneal iPSC in differentiating media (58-year-old female, 59- and 54-year-old males, denoted as N1, N2, and N3, respectively). (B, D, F) Normal iPSC differentiation and cell proliferation. (G, I, K) Three keratoconus iPSC in differentiating media (41-year-old female, 31- and 44-year-old males, denoted as K1, K2, and K3, respectively). (H, J, L) Keratoconus iPSC differentiation and cell proliferation. Differentiation and proliferation were affected in KC iPSC-derived keratocytes. (M) Quantification of number of differentiated cells. (N, O) Effects of inhibition of Pi3 kinase by LY (N) Differentiation of normal stem cells in absence of the inhibitor, and (O) in the presence of the inhibitor. Pi3 kinase inhibition severely affects differentiation and proliferation of normal iPSC-derived keratocytes.
Date of download: 10/29/2017
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