1. Signal transduction Cellular response
Spleen tyrosine kinase
Receptors:
Classical immunoreceptors
Receptors co-opting ITAM signaling (integrins, IFN receptors, RANK)
Interdomain A
Interdomain B
Receptor
SH2
SH2
Kinase
Plasma membrane
Transmembrane adaptor
Signal transduction
ITAM
Target cells:
Hematopoietic cells (T cells, B cells, NK cells, granulocytes, mast cells, RBCs, platelets)
Non-hematopoietic cells (dendritic cells, osteoclasts, synoviocytes, hepatocytes, smooth muscle cells, epithelial cells, endothelial cells, fibroblasts, neurones) P P
Cellular response
Cytoskeletal changes
Reactive oxygen species (ROS) production
Differentiation, proliferation, survival
Cytokine release