1. Effect of gas density on aerosol delivery from a pressurized metered-dose inhaler (pMDI) and jet nebulizer. A. Albuterol was administered via a pMDI and chamber spacer in an unheated dry ventilator circuit containing air, 100% oxygen, or several mixtures of helium-oxygen (80/20, 70/30, 60/40, and 50/50). Albuterol delivery from a pMDI (percentage of nominal dose) was inversely related (r = −0.98; p < 0.005) to gas density. B. Albuterol was administered with a jet nebulizer operated at a constant flow of 6 L/min of air, 100% oxygen, or helium-oxygen mixtures (as above) and albuterol output from the nebulizer was measured. Albuterol output from the nebulizer was positively correlated (r = 0.94; p < ) with the density of gas used to operate the nebulizer. (Reprinted with permission of the American Thoracic Society. Copyright © 2012 American Thoracic Society. Goode ML, Fink JB, Dhand R, et al. Improvement in aerosol delivery with helium-oxygen mixtures during mechanical ventilation. Am J Respir Crit Care Med. 2001;163:109–114. Official Journal of the American Thoracic Society.)
Source: Chapter 63. Bronchodilator Therapy, Principles and Practice of Mechanical Ventilation, 3e
Citation: Tobin MJ. Principles and Practice of Mechanical Ventilation, 3e; 2013 Available at: Accessed: October 29, 2017
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