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Solid-State Chemistry of Ambroxol Theophylline-7-Acetate

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1 Solid-State Chemistry of Ambroxol Theophylline-7-Acetate
Anastasia Foppoli, Lucia Zema, Andrea Gazzaniga, Mino R. Caira, Luigi R. Nassimbeni, Evan Borkum, Ruggero Bettini, Ferdinando Giordano  Journal of Pharmaceutical Sciences  Volume 96, Issue 5, Pages (May 2007) DOI: /jps.20951 Copyright © 2007 Wiley‐Liss, Inc. Terms and Conditions

2 Figure 1 Structural formulas of (a) AMB, (b) TAA, and (c) ACE.
Journal of Pharmaceutical Sciences  , DOI: ( /jps.20951) Copyright © 2007 Wiley‐Liss, Inc. Terms and Conditions

3 Figure 2 PXRD patterns of ACE crystal phases: (a) Form I, (b) Form II, (c) ACE · H2O, (d) ACE · 1,4-dioxane, (e) ACE · nMeOH, and (f) ACE · nEtOH. Journal of Pharmaceutical Sciences  , DOI: ( /jps.20951) Copyright © 2007 Wiley‐Liss, Inc. Terms and Conditions

4 Figure 3 DSC (—) and TGA (---) traces of ACE crystal phases: (a) Form I, (b) Form II, (c) ACE · H2O, (d) ACE · 1,4-dioxane, (e) ACE · nMeOH, and (f) ACE · nEtOH. Journal of Pharmaceutical Sciences  , DOI: ( /jps.20951) Copyright © 2007 Wiley‐Liss, Inc. Terms and Conditions

5 Figure 4 DSC and TGA traces of pure (a) AMB, (b) TAA, and (c) ACE.
Journal of Pharmaceutical Sciences  , DOI: ( /jps.20951) Copyright © 2007 Wiley‐Liss, Inc. Terms and Conditions

6 Figure 5 Thermal behavior of TAA–AMB mixtures (curve a: xAMB = 0.1; curve b: xAMB = 0.3; curve c: xAMB = 0.8). Journal of Pharmaceutical Sciences  , DOI: ( /jps.20951) Copyright © 2007 Wiley‐Liss, Inc. Terms and Conditions

7 Figure 6 Phase diagram of the TAA–AMB binary system. Solid lines represent the calculated liquidus curves; experimental points: (♦) melting of AMB, (*) recrystallization of the interaction compound, (▴) eutectic fusion, (●) final fusion, (▪) melting of pure solid phases (TAA, ACE, and AMB). Journal of Pharmaceutical Sciences  , DOI: ( /jps.20951) Copyright © 2007 Wiley‐Liss, Inc. Terms and Conditions

8 Figure 7 Scheme of relationships between ACE polymorphs and solvates (▵ refers to the addition of heat). Journal of Pharmaceutical Sciences  , DOI: ( /jps.20951) Copyright © 2007 Wiley‐Liss, Inc. Terms and Conditions

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