1. From: Propofol Attenuated Acute Kidney Injury after Orthotopic Liver Transplantation via Inhibiting Gap Junction Composed of Connexin 32
Anesthes. 2015;122(1): doi: /ALN
Figure Legend:
Propofol (pro)-attenuated gap junction function of kidney tissue and kidney damage following autologous orthotopic liver transplantation (AOLT). (A) “Scrape-and-load” assay was used to valuate functional gap junction in kidney tissue. Rats were treated with propofol (pro, 50 mg/kg) or corresponding solvent for 3 days intraperitoneally before “Scrape-and-load” assay. (B) Effects of propofol (pro, 50 mg/kg per day for 3 days, intraperitoneally) on expression of connexin32 (Cx32) after AOLT. (C) Effects of propofol (pro, 50 mg/kg, 3 days, intraperitoneally) on remote kidney damage of rats induced by AOLT (hematoxylin–eosin staining; original magnification ×200). (D) Propofol (pro, 50 mg/kg per day, for 3 days, intraperitoneally) attenuated serum creatinine (Cr) and blood urea nitrogen (BUN) increase of rats induced by AOLT. (E) Propofol (pro, 50 mg/kg day, for 3 days, intraperitoneally) attenuated H2O2 and 15-F2t-Isop levels of rats induced by AOLT. Every group contains eight samples, n = 8. *P < 0.05 versus sham; #P < 0.05 versus AOLT group. Vehicle control of propofol is lipid, which has no effects on the above-mentioned parameters (see fig. 1, Supplemental Digital Content 1,
Date of download: 10/30/2017
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