1. From: Impact of P-Glycoprotein on Blood–Retinal Barrier Permeability: Comparison of Blood–Aqueous Humor and Blood–Brain Barrier Using Mdr1a Knockout Rats
Invest. Ophthalmol. Vis. Sci ;55(7): doi: /iovs
Figure Legend:
The initial uptake of [3H]verapamil by the retina (A), aqueous humor (B), and brain (C) in wild-type (closed circles) and mdr1a knockout (open circles) rats. In the integration plot analysis, [3H]verapamil was injected into the femoral vein. Points represent means ± SE (n = 3 rats). The line represents the regression line using the initial tissue uptake data in wild-type (solid line) and mdr1a knockout (dashed line) rats. The slope represents the apparent influx permeability clearance (Kin ).
Date of download: 10/30/2017
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