1. Prevention of Knee Osteoarthritis in Overweight Females: The First Preventive Randomized Controlled Trial in Osteoarthritis 
Jos Runhaar, PhD, Marienke van Middelkoop, PhD, Max Reijman, PhD, Sten Willemsen, PhD, Edwin H. Oei, PhD, MD, Dammis Vroegindeweij, PhD, MD, Gerjo van Osch, PhD, Bart Koes, PhD, Sita M.A. Bierma-Zeinstra, PhD 
The American Journal of Medicine 
Volume 128, Issue 8, Pages e4 (August 2015)
DOI: /j.amjmed
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2. Figure
Flow-chart of participants in the PRevention of knee Osteoarthritis in Overweight Females (PROOF) study. DEP = diet-and-exercise program.
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3. Appendix Figure 1
Mean quality of life (EuroQol) scores within randomized intervention groups.
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4. Appendix Figure 2
Mean WOMAC pain scores (range 0-100; higher scores mean more pain) within randomized intervention groups.
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5. Appendix Figure 3
Mean WOMAC function scores (range 0-100; higher scores mean less function) within randomized intervention groups.
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6. Appendix Figure 4
Actual weight loss (negative values represent weight gain from baseline) within randomized intervention groups.
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