1. Comparison of subcutaneous dexmedetomidine–midazolam versus alfaxalone– midazolam sedation in leopard geckos (Eublepharis macularius) 
Grayson A. Doss, Dustin M. Fink, Kurt K. Sladky, Christoph Mans 
Veterinary Anaesthesia and Analgesia 
DOI: /j.vaa
Copyright © 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions

2. Figure 1
Median (± twenty-fifth and seventy-fifth percentiles) heart rate of leopard geckos (n=9) administered a combination of dexmedetomidine (0.1 mg kg−1) and midazolam (1.0 mg kg−1) (treatment D–M) or alfaxalone (15 mg kg−1) and midazolam (1.0 mg kg−1) (treatment A–M) subcutaneously. *Significantly different from baseline (−5 minutes) within the same treatment (p < 0.05). †Significantly different between treatments at the same time point (p < 0.05).
Veterinary Anaesthesia and Analgesia DOI: ( /j.vaa )
Copyright © 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions

3. Figure 2
Median (± twenty-fifth and seventy-fifth percentiles) respiratory rate of leopard geckos (n=9) administered a combination of dexmedetomidine (0.1 mg kg−1) and midazolam (1.0 mg kg−1) (treatment D–M) or alfaxalone (15 mg kg−1) and midazolam (1.0 mg kg−1) (treatment A–M) subcutaneously.
Veterinary Anaesthesia and Analgesia DOI: ( /j.vaa )
Copyright © 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions

4. Figure 3
Mean (± standard error of the mean) change from baseline respiratory rate over time in leopard geckos (n=9) administered a combination of dexmedetomidine (0.1 mg kg−1) and midazolam (1.0 mg kg−1) (treatment D–M) or alfaxalone (15 mg kg−1) and midazolam (1.0 mg kg−1) (treatment A–M) subcutaneously. *Significantly different between treatments at the same time point (p<0.05).
Veterinary Anaesthesia and Analgesia DOI: ( /j.vaa )
Copyright © 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions

5. Figure 4
Median (± twenty-fifth and seventy-fifth percentiles) sedation scores of leopard geckos (n=9) administered a combination of dexmedetomidine (0.1 mg kg−1) and midazolam (1.0 mg kg−1) (treatment D–M) or alfaxalone (15 mg kg−1) and midazolam (1.0 mg kg−1) (treatment A–M) subcutaneously. *Significantly different from baseline (–5 minutes) within the same treatment (p < 0.05). †Significantly different between treatments at the same time point (p<0.05).
Veterinary Anaesthesia and Analgesia DOI: ( /j.vaa )
Copyright © 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions

6. Figure 5
Recovery times of nine leopard geckos following SC administration of atipamezole (1.0 mg kg−1) and flumazenil (0.05 mg kg−1) (treatment D–M) or flumazenil (treatment A–M) 45 minutes after the injection of dexmedetomidine (0.1 mg kg−1) and midazolam (1.0 mg kg−1) (D–M) or alfaxalone (15 mg kg−1) and midazolam (1.0 mg kg−1) (A–M). Time 0 was the time of administration of D–M or A–M. Antagonists were administered at 45 minutes, and physiological variables, reflexes and behavioral parameters were then evaluated until recovery, starting at the 50 minute time point. Sedation was defined as reduced or absent palpebral reflex, righting reflex, jaw tone, escape response, and presence or absence of spontaneous movement or movement in response to a noxious stimulus. SC, subcutaneous.
Veterinary Anaesthesia and Analgesia DOI: ( /j.vaa )
Copyright © 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions