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Cardiovascular Outcomes Trials in Diabetes: The Truth, the Whole Truth, and Nothing But the Truth.

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Presentation on theme: "Cardiovascular Outcomes Trials in Diabetes: The Truth, the Whole Truth, and Nothing But the Truth."— Presentation transcript:

1 Cardiovascular Outcomes Trials in Diabetes: The Truth, the Whole Truth, and Nothing But the Truth

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4 Program Goals

5 The Growing Diabetes Pandemic

6 Approved Antidiabetic Medications

7 Cardiovascular benefits to tighter HbA1c control?

8 Outcomes of Better Glycemic Control in T2D: UKPDS and Post-UKPDS

9 Should Hyperglycemia in Diabetes Be Treated Aggressively?

10 DCCT/EDIC: Intensive Diabetes Therapy in T1D

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12 Counseling a Patient With Newly Diagnosed T2D

13 Sulfonylureas

14 Safety of Sulfonylureas

15 Safety of Sulfonylureas (cont)

16 The CAROLINA Study: Phase 3 Results

17 Rosiglitazone Data Reanalyzed

18 Results of a Reevaluation of Cardiovascular Outcomes in the RECORD Trial

19 Thiazolidinediones

20 Pioglitazone: The PROactive Study

21 Guidance for Industry: Diabetes Mellitus -- Evaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat T2D

22 Impact of FDA Guidance: December 2008

23 Incretin-Based Drugs

24 Incretin-Based Drugs (cont)

25 Warnings and Precautions

26 SGLT-2 Inhibitors

27 SGLT-2 Inhibitors (cont)

28 SAVOR-TIMI 53 trial

29 Take-Home Messages

30 Abbreviations

31 Abbreviations (cont)

32 Abbreviations (cont)

33 References

34 References (cont)

35 References (cont)

36 References (cont)

37 References (cont)

38 References (cont)

39 References (cont)

40 References (cont)


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