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Fiberoptic Bronchoscopy in Ventilated Patients

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1 Fiberoptic Bronchoscopy in Ventilated Patients
Jean-Louis Trouillet, M.D., Marguerite Guiguet, M.S., Claude Gibert, M.D., Jean-Yves Fagon, M.D., Didier Dreyfuss, M.D., Françoise Blanchet, Pharm.D., Jean Chastre, M.D.  CHEST  Volume 97, Issue 4, Pages (April 1990) DOI: /chest Copyright © 1990 The American College of Chest Physicians Terms and Conditions

2 FIGURE 1 Sequential measurements of PaO2 (mean ±2 SEM) in ventilated patients undergoing flexible fiberoptic bronchoscopy; FIo2 was adjusted to 0.8 at 20 minutes before endoscopy and was maintained unchanged during study. T1, Control time; T2, five minutes after IV premedication; T3, at end of procedure, with fiberoptic bronchoscope still in place; T4, 15 minutes after removing endoscope; and T5, two hours after examination. Asterisk indicates significant differences vs any other time (p<0.01). Dagger indicates significant differences vs T1, T2, or T, (p<0.01). CHEST  , DOI: ( /chest ) Copyright © 1990 The American College of Chest Physicians Terms and Conditions

3 FIGURE 2 Changes in PaCO2 and [H+] (mean ± 2 SEM) during study. Sequential times are the same as in Figure 1. Value for T2 was omitted because of similarity to T1, Asterisks indicate significant differences vs any other time (p<0.01). CHEST  , DOI: ( /chest ) Copyright © 1990 The American College of Chest Physicians Terms and Conditions

4 FIGURE 3 Sequential measurements of heart rate and systolic blood pressure (mean ±2 SEM) in ventilated patients undergoing flexible fiberoptic bronchoscopy. Times are the same as in Figure 1. Asterisks indicate p<0.01 in comparison with any other time. CHEST  , DOI: ( /chest ) Copyright © 1990 The American College of Chest Physicians Terms and Conditions

5 FIGURE 4 Main central hemodynamic data (mean ±2 SEM) in 31 patients in whom Swan-Ganz catheter had been inserted. Note that these patients were more severely ill than others (APACHE score, 19.5; radiologic score, 6.6; PaO2 at T1, 166 mm Hg; ARDS present in ten; and 18 patients required inotropic agents). CO, Cardiac-output; PCWP, pulmonary capillary wedge pressure; and SVR, systemic vascular resistance. Asterisks indicate significant differences vs any other time (p<0.01). CHEST  , DOI: ( /chest ) Copyright © 1990 The American College of Chest Physicians Terms and Conditions


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