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Ultraslow thrombolytic therapy: A novel strategy in the management of PROsthetic MEchanical valve Thrombosis and the prEdictors of outcomE: The Ultra-slow PROMETEE trial Mehmet Özkan, MD, Sabahattin Gündüz, MD, Ozan Mustafa Gürsoy, MD, Süleyman Karakoyun, MD, Mehmet Ali Astarcıoğlu, MD, Macit Kalçık, MD, Ahmet Çağrı Aykan, MD, Beytullah Çakal, MD, Zübeyde Bayram, MD, Ali Emrah Oğuz, MD, Emre Ertürk, MD, Mahmut Yesin, MD, Tayyar Gökdeniz, MD, Nilüfer Ekşi Duran, MD, Mustafa Yıldız, MD, Ali Metin Esen, MD American Heart Journal Volume 170, Issue 2, Pages e1 (August 2015) DOI: /j.ahj Copyright © 2015 Elsevier Inc. Terms and Conditions
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Figure 1 Study algorithm. Abbreviations as in Table I.
American Heart Journal , e1DOI: ( /j.ahj ) Copyright © 2015 Elsevier Inc. Terms and Conditions
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Figure 2 A, Relative risks (RR) and 95% CIs of several categorical variables for TT failure are presented as a forest plot graph. B, The comparison of the thrombus area, valve area, and DSA between successful and failed cases undergoing thrombolysis is represented as box plot graphs (B). Abbreviations: LCL, lower confidence level; UCL, upper confidence level; A-fib, atrial fibrillation. Other abbreviations as in Table I. American Heart Journal , e1DOI: ( /j.ahj ) Copyright © 2015 Elsevier Inc. Terms and Conditions
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Figure 3 Cumulative success and complication rates of thrombolysis sessions. American Heart Journal , e1DOI: ( /j.ahj ) Copyright © 2015 Elsevier Inc. Terms and Conditions
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Figure 4 Demonstration of serial 2D and real-time 3D (RT-3D) TEE images of a patient with obstructive PVT (arrows) undergoing TT (A, upper and lower parts). B and C, Serial 2D (upper parts) and RT-3D TEE (lower parts) images performed after each 25-mg t-PA session. The size and area of thrombus decreased after the first thrombolysis session (B), and complete lysis was achieved after the second session (C). American Heart Journal , e1DOI: ( /j.ahj ) Copyright © 2015 Elsevier Inc. Terms and Conditions
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