Ch. 14 The Autonomic Nervous System

Ch. 14 The Autonomic Nervous System
Parasympathetic Sympathetic

Somatic nervous system
Review Central nervous system (CNS) Peripheral nervous system (PNS) Sensory (afferent) division Motor (efferent) division Somatic nervous system Autonomic nervous system (ANS) Sympathetic division Parasympathetic division

Cranial Nerves: some with parasympathetic
REVIEW … Cranial Nerves: some with parasympathetic Spinal Nerves: particular regions have parasympathetic and other sympathetic Rami communicantes Ventral root Dorsal root Dorsal and ventral rootlets of spinal nerve Dorsal root ganglion Ventral ramus of spinal nerve Spinal nerve Rami communicantes

CH. 14 The Autonomic Nervous System
I. Introduction– differences in Somatic Motor & Autonomic Motor Effectors Efferent (Motor) Pathways 1. *ANS: Number of Neurons? a) Preganglionic Neuron *- Axon is called? b) Ganglionic Neuron 2. ANS Ganglion Ganglion Preganglionic Neuron Ganglionic Neuron

I. Introduction … Slide 6 B. Efferent pathways …
C. Neurotransmitters & Responses Neurotransmitters: Which of the below nuerotransmitters for Sympathetic, Which for Parasympathetic - ANS: *Norepinephrine for: & *Acetylcholine for: Organ (Effector) Response:

SOMATIC MOTOR Versus AUTONOMIC
Skeletal Muscles One Neuron w/ cell body in Ventral Horn of Spinal cord No Ganglion Axons travel in cranial and spinal nerves to muscles Neurotransmitters: Ach Smooth & Cardiac Muscles Two Neurons Cell body of presynaptic neuron in Lateral Horn of Spinal cord = Preganglionic Neuron Autonomic Ganglion Cell Body of postsynaptic neuron in ganglion = Ganglionic Neuron Most axons travel in cranial & spinal nerves to effectors Neurotransmitters: Ach and NE

Somatic Motor vs. Autonomic Physiology
Neuro- transmitter at effector Cell bodies in central nervous system Effector organs Peripheral nervous system Effect Single neuron from CNS to effector organs SOMATIC NERVOUS SYSTEM ACh + Heavily myelinated axon Stimulatory Skeletal muscle Two-neuron chain from CNS to effector organs ACh NE Unmyelinated postganglionic axon SYMPATHETIC Ganglion Lightly myelinated preganglionic axons Epinephrine and norepinephrine + ACh Stimulatory or inhibitory, depending on neuro- transmitter and receptors on effector organs AUTONOMIC NERVOUS SYSTEM Adrenal medulla Blood vessel ACh ACh Smooth muscle (e.g., in gut), glands, cardiac muscle PARASYMPATHETIC Lightly myelinated preganglionic axon Unmyelinated postganglionic axon Ganglion Acetylcholine (ACh) Norepinephrine (NE) Figure 14.2

II. ANS Divisions & Functions
Dual Innervations: Sympathetic vs. Parasympathetic Some Organ systems have both equally Some have one or the other Dominate Rarely does an organ system only get input from only one

II. ANS Divisions … B. Role of the Parasympathetic Division Peace
* Do All Below Body maintenance: Energy: Organs while Relaxing BP: Heart: respiratory rates: Gastrointestinal activity: Urinary Sys Pupils: Ciliary muscles:

C. Role of the Sympathetic Division Stress
* Do All Below Fight or Flight Mobilizes body for action or threat BP: Blood flow to muscles & heart: _____ Bronchioles: __________ Blood Glucose levels: ______ via Liver Heart and Respiratory rates: _____________ Digestive & Urinary Systms:

III. ANS Anatomy Overview of differences Parasympathetic Division
Origin Sites Relative Lengths of their Fibers Location of their Ganglion Parasympathetic Division *Origin: preganglionic neuron cell body is in: a) *Sacral b) *Cranial GANGLIA = Terminal (Collateral) Ganglia contains: - Locations: Cranial & Sacral Outflow  Ciliary ganglion Eye CN III Lacrimal gland CN VII Pterygopalatine ganglion Pterygopalatine ganglion CN IX Nasal mucosa CN X Submandibular ganglion Submandibular and sublingual glands Otic ganglion Parotid gland Heart Cardiac and pulmonary plexuses Lung Liver and gallbladder Celiac plexus Stomach Pancreas S2 Large intestine S4 Pelvic splanchnic nerves Small intestine Inferior hypogastric plexus Rectum Urinary bladder and ureters Genitalia (penis, clitoris, and vagina) NEXT SLIDE

III. ANS Anatomy … B. Parasympathetic Division
CN III Ciliary ganglion Eye 3. Cranial & Sacral Outflow Lacrimal gland CN VII Pterygopalatine ganglion Pterygopalatine ganglion CN IX Nasal mucosa CN X Submandibular ganglion Submandibular and sublingual glands Otic ganglion Parotid gland : Pupil & Lens Heart Midbrain  Cardiac and pulmonary plexuses Para for Head Lung Pons  Liver and gallbladder Medulla  Celiac plexus Stomach 90% fibers Medulla  Pancreas S2 (distal ½) Large intestine S4 Pelvic splanchnic nerves Small intestine Lateral Gray Horn  Splanchnic n. Inferior hypogastric plexus Rectum Urinary bladder and ureters Genitalia (penis, clitoris, and vagina)

C. Sympathetic Division
Innervates more organs Pathway more complicated 1. Origin: *Spinal Cord? Preganglionic Neuron *Cell Body in: Preganglionic Axons  ventral rami, then go through White Rami Communicantes - Is myelinated Spinal cord Dorsal root Ventral root Sympathetic trunk ganglion trunk Ventral ramus of spinal nerve White ramus communicans (a) Location of the sympathetic trunk

C. Sympathetic Division …
3. GANGLIA = Sympathetic Trunk Ganglia (Chain or Paravertebral Ganglia) *Number: = Are clusters of neurons linked by axonal bridges *Contain Cell Body of ? Spinal cord Dorsal root Ventral root Sympathetic trunk ganglion trunk Ventral ramus of spinal nerve White ramus communicans (a) Location of the sympathetic trunk

3. GANGLIA = Sympathetic Trunk Ganglia …
Levels: 3 C, 12T, 4L, 4S Cervical & Sacral Ganglia do not directly connect to spinal cord, BUT ascend & descend via bridges Eye Lacrimal gland Pons Nasal mucosa Sympathetic trunk (chain) ganglia 23 paired paravertebral ganglia Blood vessels; skin (arrector pili muscles and sweat glands) Superior cervical ganglion Salivary glands Middle cervical ganglion Heart Inferior cervical ganglion Cardiac and pulmonary plexuses Lung T1 Greater splanchnic nerve Lesser splanchnic nerve Liver and gallbladder Celiac ganglion L2 Stomach White rami communicantes Superior mesenteric ganglion Spleen Adrenal medulla Kidney Sacral splanchnic nerves Lumbar splanchnic nerves Inferior mesenteric ganglion Small intestine Large intestine Rectum Preganglionic Postganglionic Genitalia (uterus, vagina, and penis) and urinary bladder Figure 14.6

C. Sympathetic Division …
4. Once preganglionic axon is in trunk ganglia, one of the following occurs: a or b Synapse in Chain Ganglia with ganglionic neuron Then: postganglionic axon travels out the Gray Rami same level  ventral rami/spinal nerve  organ Synapse at the same level i Synapse at a higher or lower level ii

4. Once preganglionic axon is in trunk …
Examples: Arm & Legs--skin: Sweat glands, Arrector pili muscles; smooth muscle in Blood Vessels, Heart, Lungs, Lateral horn (visceral motor zone) Ventral ramus of spinal nerve Gray ramus communicans Ventral root Skin (arrector pili muscles and sweat glands) White ramus communicans Sympathetic trunk ganglion To effector 1 Synapse at the same level Blood vessels Figure 14.5b (1 of 3)

4. Once preganglionic axon is in trunk … Examples …
Eye Lacrimal gland Pons Nasal mucosa Sympathetic trunk (chain) ganglia Blood vessels; skin (arrector pili muscles and sweat glands) Superior cervical ganglion Salivary glands Middle cervical ganglion Heart Inferior cervical ganglion Cardiac and pulmonary plexuses Lung T1 Greater splanchnic nerve Lesser splanchnic nerve Liver and gallbladder Celiac ganglion L2 Stomach White rami communicantes Superior mesenteric ganglion Spleen Adrenal medulla Sacral splanchnic nerves Kidney Lumbar splanchnic nerves 2 Inferior mesenteric ganglion Small intestine Large intestine Rectum Preganglionic Postganglionic Genitalia (uterus, vagina, and penis) and urinary bladder Figure 14.5b (2 of 3)

Pass through trunk without synapsing or going out the gray rami.
Where: T5 – L2 Organs served: abdominal organs GANGLIA = Collateral Ganglia Location: Anterior to chain Serve: abdominal organs - Splanchnic Nerves: Dorsal Root Ganglion Trunk Ganglion Collateral Ganglion Splanchnic Nerve T1 Greater splanchnic nerve Lesser splanchnic nerve Liver and gallbladder Celiac ganglion L2 Stomach White rami communicantes Superior mesenteric ganglion Spleen Adrenal medulla Sacral splanchnic nerves Kidney Lumbar splanchnic nerves 2 Inferior mesenteric ganglion Small intestine Large intestine Rectum Preganglionic Postganglionic Genitalia (uterus, vagina, and penis) and urinary bladder

ii) Go Directly to Adrenal Gland:
b)…ii) Splanchnic Nerves … Collateral Ganglia … ii) Go Directly to Adrenal Gland: synapse with neurons in Medulla of Adrenal Gland  hormones Hormones released are the same as the neurotransmitters of same name– Epinephrine & Norepinephrine T1 Greater splanchnic nerve Lesser splanchnic nerve Liver and gallbladder Celiac ganglion L2 Stomach White rami communicantes Superior mesenteric ganglion Spleen Adrenal medulla Sacral splanchnic nerves Kidney Lumbar splanchnic nerves 2 Inferior mesenteric ganglion Small intestine Large intestine Rectum Preganglionic Postganglionic Genitalia (uterus, vagina, and penis) and urinary bladder Adrenal medulla Hormones ACh

Broad Influence of preganglionic neurons: on diverse array of organs
Each Preganglionic axon branches: 10-20 Pathways: all above possible (see 4-a & b) Result: Diverse organs targeted to act together - Function: better emergency response Example: As Response to Threat Heart and breathing rate increase, blood flow to skeletal muscles increases, blood flow to digestive organs decreases, and sweat gland output increases, … T1 L2

Parasympathetic vs. Sympathetic: structural differences
Location: Thoracolumbar Preganglionic Axon: short Travels from lateral horn  Ventral root --> white rami  Trunk Ganglia. THEN: 1) Synapse  gray rami c.  Ventral rami/Spinal Nerve  peripheral nerve  organ 2)  Splanchnic nerves  Collateral Ganglia & synapse  organs OR pass thru to Adrenal G. Postganglionic Axon: long Ganglia: Trunk Ganglia close to the spinal cord and Collateral Ganglia anterior to and farther away from the spinal cord Location: Craniosacral Preganglionic Axon: long Travels from 1) lateral horn  ventral root  ventral rami  nerves  Terminal Ganglia Organ OR 2) brain  nerve  Terminal Ganglia  Organ Postganglionic Axon: short Ganglia: Terminal Ganglia in or near effectors

ANS anatomy-Differences
Parasympathetic Sympathetic Eye Eye Brain stem Salivary glands Skin* Cranial Salivary glands Sympathetic ganglia Heart Cervical Lungs Lungs T1 Heart Stomach Thoracic Stomach Pancreas Liver and gallbladder Pancreas L1 Liver and gallbladder Adrenal gland Lumbar Bladder Bladder Genitals Genitals Sacral Figure 14.3

IV. Physiology A. Interactions of the Autonomic Divisions
Dynamic Antagonism: Most organs have both Symp & Parasymp controlling them FUNCTION: precise control of visceral activity & Homeostasis Autonomic Tone: When Para or Sym normally Dominates certain organs Sympathetic Tone Sympathetic controls: blood vessels  blood pressure

Normal state of Blood vessels: are always partially constricted
2-a … Sympathetic Tone … = vasomotor tone Normal state of Blood vessels: are always partially constricted Exception: skeletal muscles blood vessels dilated Parasympathetic Tone Parasympathetic division dominates: heart, digestive and urinary tract organs Sympathetic division overrides: during Stress

3. Cooperative Effects SEX
Parasympathetic Sympathetic Eye Eye SEX Brain stem Salivary glands Skin* Parasympathetic fibers cause vasodilation = erection of penis or clitoris Sympathetic fibers = ejaculation in males, contraction of vagina Cranial Salivary glands Sympathetic ganglia Heart Cervical Lungs Lungs T1 Heart Stomach Thoracic Stomach Pancreas Liver and gallbladder Pancreas L1 Liver and gallbladder Adrenal gland Lumbar Bladder Bladder Genitals Genitals Sacral

4. Unique Roles of Sympathetic Division
Adrenal medulla, sweat glands, arrestor pili muscles, kidneys, and most blood vessels receive only sympathetic fibers The sympathetic division controls factors needed to Respond to STRESS: Heat regulation: Kidneys and B.P. to: Release of renin from kidneys to increase B.P. Metabolic effects: metabolic rates of cells blood glucose levels Mobilizes fats for fuel Skeletal muscles contract: due to Adrenal hormones

5. Localized Versus Diffuse Effects
Parasympathetic division: short-lived, highly localized control over effectors Sympathetic division: long-lasting, body-wide effects (NE and E breakdown slowly in liver) Two-neuron chain from CNS to effector organs ACh NE Unmyelinated postganglionic axon SYMPATHETIC Ganglion Lightly myelinated preganglionic axons Epinephrine and norepinephrine + ACh Stimulatory or inhibitory, depending on neuro- transmitter and receptors on effector organs AUTONOMIC NERVOUS SYSTEM Adrenal medulla Blood vessel ACh ACh Smooth muscle (e.g., in gut), glands, cardiac muscle PARASYMPATHETIC Lightly myelinated preganglionic axon Unmyelinated postganglionic axon Ganglion

B. Visceral Reflexes 1. Visceral Sensory function:
Similar to Somatic Reflexes 1. Visceral Sensory function: Sensory information: chemical changes, stretch, and irritation Cell Body location: Dorsal Root Ganglia & Cranial Nerve Ganglia 2. Integration center: Interneurons in spinal cord or brain 3. Visceral Motor Neuron– preganglionic neuron: Lateral Horn of Spinal Cord Sympathetic: Axon synapses in Chain Ganglia  ganglionic, then neuron’s axon  Autonomic nerves (splanichic) or spinal nerves  organ/glands

Visceral Reflexes Stimulus Dorsal root ganglion Sensory receptor
in viscera 1 Visceral sensory neuron Spinal cord 2 Integration center • May be preganglionic neuron (as shown) • May be a dorsal horn interneuron • May be within walls of gastrointestinal tract 3 Autonomic ganglion Efferent pathway (two-neuron chain) • Preganglionic neuron • Ganglionic neuron 4 5 Visceral effector Response Figure 14.7

Examples: emptying bladder and rectum
2. Parasympathetic: Axon synapses in terminal ganglia  ganglionic neuron’s axon  organ Examples: emptying bladder and rectum Example: Baroreceptors in Carotid Artery and Aortic Arch detect stretch when blood pressure or volume increase  glossopharyngeal & vagus nerves  Integration Center is in the Medulla Preganglionic Neuron in Medulla  vagus nerve  terminal ganglion with ganglionic neuron  (Inhibition of sympathetic affect axon to spinal cord Trunk Ganglia with ganlionic neuron  axon  spinal nerve  blood vessels to cause)

C. Referred Pain Visceral pain afferents travel same pathway as somatic pain fibers Pain stimuli in viscera perceived as somatic Heart Lungs and diaphragm Liver Heart Gallbladder Liver Appendix Stomach Pancreas Small intestine Ovaries Colon Kidneys Urinary bladder Ureters Figure 14.8

V. Control of ANS Functioning
Communication at subconscious level Cerebral cortex (frontal lobe) Limbic system (emotional input) Hypothalamus Overall integration of ANS, the boss Brain stem (reticular formation, etc.) Regulation of pupil size, respiration, heart, blood pressure, swallowing, etc. Spinal cord Urination, defecation, erection, and ejaculation reflexes Figure 14.9

A. Hypothalamus Medulla
Overall Functions: Major controller of Autonomic & Endocrine activities Integrates inputs: top of heirarchy 2. Centers for: heart, blood pressure, body temp, water balance, emotional states, biological drives 3. Certain Output is direct to and by way of lower brain regions, especially the nuclei of the Reticular Formation (in brain stem) Interacts with other Brain Regions Medulla Heart Respiration Gastrointestinal Activities Pons

D. Midbrain: Pupil diameter and lens focus
C. Pons: Respiration D. Midbrain: Pupil diameter and lens focus E. Cerebral Cortex: Emotional Aspects Unconscious modification via Limbic Association Region Spinal Cord Level: Defecation & micturition, erection, and ejaculation which are then affected by conscious cerebral cortex

END Review Questions Follow

Review Questions Body maintenance is regulated by the _______________ division and its nerves arise from the ____________ regions. Mobilization is regulated by the ___________ division and its nerves arise from the _____________ region parasympathetic craniosacral sympathetic thoracolumabar

Review Questions Sympathetic fibers that control sweat glands and arrector pili muscles synapse in the ______________ _______ ganglia. Pathways that serve the intestines and liver synapse in ____________ ganglia. All preganglionic ANS figers release ____________. Sympathetic post ganglionic fibers tend to release _______________. sympathetic trunk collateral Acetylcholine (ACh) norepinephrine (NE)

Kidney, sweat glands, adrenal medulla
Review Questions Most blood vessel smooth muscle and arrector pili are only innervated by _____________ fibers. What are two other structures that only receive these fibers? Which region of the brain is king of the ANS? How is it linked to conscious awareness? sympathetic Kidney, sweat glands, adrenal medulla Hypothalamus Limbic System

Somatic Motor vs. Autonomic Physiology
Neuro- transmitter at effector Cell bodies in central nervous system Effector organs Peripheral nervous system Effect Single neuron from CNS to effector organs SOMATIC NERVOUS SYSTEM ACh + Heavily myelinated axon Stimulatory Skeletal muscle Two-neuron chain from CNS to effector organs ACh NE Unmyelinated postganglionic axon SYMPATHETIC Ganglion Lightly myelinated preganglionic axons Epinephrine and norepinephrine + ACh Stimulatory or inhibitory, depending on neuro- transmitter and receptors on effector organs AUTONOMIC NERVOUS SYSTEM Adrenal medulla Blood vessel ACh ACh Smooth muscle (e.g., in gut), glands, cardiac muscle PARASYMPATHETIC Lightly myelinated preganglionic axon Unmyelinated postganglionic axon Ganglion Acetylcholine (ACh) Norepinephrine (NE) Figure 14.2

Ch. 14 The Autonomic Nervous System

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