1. Controls and Functions
Kineticlass 6
Controls and Functions

2. Kineticlass navigation
VMCVM students in “Normal Animal” ignore.
PK glossary, equation help, AND this presentation.
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3. Kineticlass modules A module consists of these sections: Objectives
What the instructor hopes you will learn.
Significance
What does this mean for clinical patients (therapeutics)
Exercise
Steps you take to complete the module.
Questions
Self assessment (access to a key is provided)

4. Kineticlass exercises
An exercise includes the following:
Download (Excel worksheet)
Target Concentrations
Pharmacokinetic “end-points” for clinical effect
generally expressed as some minimum and maximum concentration
Will indicate why are these targets important.
Manipulate Dosage
Alter settings in the worksheet.
Inspect
Look at calculated values, steady-state concentrations and graphs.
Assess
A review of what was demonstrated.
Consider effects on therapy

5. View of worksheet for module 1 (initial state)
View of worksheet for module 1 (initial state). Kineticlass worksheets always show numeric data on the left and graphs on the right. Graphs may reflect a single (initial) dose or multiple doses.

6. Excel worksheets Variables Target concentrations
Graph key (rows 1 and 2)
User can set values in boxes – others locked
Target concentrations
Can be set to show various clinical targets. Minimum effective (MEC) and minimum toxic (MTC) for simulation 1.

7. Excel worksheets Calculated values Steady -state
Values determined by Vz and Clt (ONLY)
Steady -state
These values depend on kinetics, dose, and dose interval.
Assume repeated dosing
Graphs will not reflect these values unless steady state is reached on the graph.

8. Linear graph (top) provides best visualization of relevant concentrations and times. (e.g. Time above MEC)
Log graph (bottom) provides best visualization of elimination rate constant (slope) and model characteristics (one compartment in this case).

9. Simulations 1 and 2 overlap
Module 1 – Linear plot (top) and semi-log plot (bottom) of initial conditions.

10. Dose for #2 and #4 (IV) are now double those of #1 and #3 (oral).
Changing the dose does not affect Clt, Vz, Ka or F (model characteristics that are dose Independent).
Target concentrations remain the same.
Calculated values do not change. (Depend ONLY on Clt and Vz)
Steady-state values are different
#1 vs #2 and #3 vs $4. (Depend on Clt and Vz, dose and interval.)

11. Compare #1 to #2
Compare # 3 to #4
Compare #1 to #2
Compare # 3 to #4