Chemistry Faculty La Jolla Campus Scripps Original View.

Chemistry Faculty La Jolla Campus Scripps Original View

Total Synthesis and Methodologies for Drug Discovery
Phil S. Baran, Professor of Chemistry, The Scripps Research Institute, 2003-present Post Doctoral Associate 2003, Harvard University Ph. D. Chemistry 2001, The Scripps Research Institute Young investigator awards from GSK, Amgen, Roche, DuPont, AstraZeneca, Eli Lilly, BMS, and Pfizer Searle Scholar Award, 2005 NSF CAREER Award, Alfred P. Sloan Foundation Fellow, Beckman Foundation Fellow, Hirata Gold Medal, 2007 National Fresenius Award, ACS, 2007 Raymond and Beverly Sackler Prize in Physical Sciences, 2009 ACS Award in Pure Chemistry, 2010 Thieme-IUPAC Prize in Synthetic Organic Chemistry, 2010 ISHC Katrizky Heterocyclic Chemistry Award, 2011 ACS San Diego Section Distinguished Scientist Award, 2012 Fellow, AAAS, 2012-Present 33 Ph.D. and 42 Postdoctoral Students >125 Publications >250 Invited Lectures Scripps Original View Synthesis routes and methods that harness innate reactivity and embrace the logic of C–H functionalization are developed in order to procure multi-gram quantities of complex natural products as well as to invent reactions with broad utility in industrial settings.

Chemical Biology and Organocatalysis
Carlos F. Barbas, III, Professor of Chemistry and Molecular Biology The Scripps Research Institute, 1990-present Ph.D. Organic Chemistry, 1989, Texas A&M University Faculty: Department of Molecular Biology and Chemistry, TSRI, 1991-present Janet and W. Keith Kellogg II Endowed Chair, 1997-present Director, Cold Spring Harbor Laboratory Annual Fall Course “Antibody Engineering and Phage Display” 1992-present Scholar of The American Foundation for AIDS Research, Investigator Award, Cancer Research Institute, Co-recipient of Presidential Green Chemistry Award, 2003 Fellow, American Association for the Advancement of Science, 2005 Founder of the biotechnology companies Prolifaron Inc. (acquired by Alexion Pharmaceuticals in 2000), CovX Pharmaceuticals Inc. (acquired by Pfizer in 2008), and Zyngenia Inc. Tetrahedron Young Investigator Award - Bioorganic & Medicinal Chemistry, 2009 Arthur C. Cope Scholar Award (CSM), 2009 Recipient NIH Director’s Pioneer Award, 2010 Ranked among 100 top chemists of the decade by Thomson Reuters, 2011 According to ISI, among Top 1% Cited Chemists in citations in each of the areas of Chemistry, Biology, Biochemistry, and Microbiology and highly cited Researcher in 2005; h index = 86 19 Ph.D. and 92 Postdoctoral students Authored >320 scientific publications Inventor on >50 issued U.S. patents Development of new therapeutic approaches to human diseases through studies at the interface of synthetic organic chemistry, molecular biology, and medicine

Kinetic and Mechanistic Studies of Organic Reactions
Donna G. Blackmond, Professor of Chemistry The Scripps Research Institute, 2010-present Ph.D. Chemical Engineering 1984, Carnegie Mellon University, NSF Fellow Faculty: Department of Chemical Engineering, University of Pittsburgh, Associate Director, Merck & Co, Group Leader, Max-Planck-Institut für Kohlenforschung (DE), Faculty: Department of Chemistry, University of Hull (UK), Faculty: Departments of Chemistry and Chemical Engineering, Imperial College (UK), NSF Presidential Young Investigator Award, Max-Planck-Gesellschaft Award for Outstanding Women Scientists, 1998 Paul H. Emmett Award in Fundamental Catalysis, 2001 Rylander Award in Organic Reactions Catalysis, 2003 Woodward Scholar, Harvard University, Miller Institute Fellow, Berkeley, 2003 Royal Society of Chemistry Award in Process Technology, 2003 ACS A.C. Cope Scholar, 2005 Royal Society Wolfson Research Merit Award, Royal Society of Chemistry Christopher Ingold Award, 2009 > 125 Publications >200 Invited Lectures Scripps Original View Mechanistic studies in asymmetric catalysis, Studies of the emergence of biological homochirality

Natural Products and Medicinal Chemistry
Dale L. Boger, Chairman and Professor, Department of Chemistry The Scripps Research Institute, 1990-present Ph. D. Chemistry 1980, Harvard University, NSF Fellow Faculty: Department of Medicinal Chemistry, University of Kansas, Faculty: Department of Chemistry, Purdue University, Searle Scholar Award, inaugural award recipient: NIH Research Career Development Award Recipient, Alfred P. Sloan Fellow, ACS A. C. Cope Scholar, 1988 ISHC Katritzky Award in Heterocyclic Chemistry, 1997 ACS Aldrich Award for Creativity in Organic Synthesis, 1999 Paul Janssen Prize for Creativity in Organic Synthesis, 2002 Adrien Albert Medal, RSC, 2003 Elected American Academy of Arts and Sciences, 2006 ACS Guenther Award in Natural Products, 2007 Fellow, Royal Society of Chemistry, 2009 Fellow, American Chemical Society, 2010 ACS Portoghese Lecturer, 2011 ACS Hirschmann Award in Peptide Chemistry, 2013 Among Top 100 Cited Chemists Honorary Ph.D., Laurea Honors Causa, Univ. Ferrara, 2000 Editor-in-Chief: Bioorganic & Medicinal Chemistry Letters 57 Ph.D. and 160 Postdoctoral Students 530 Publications, 2 Books >600 Invited Lectures Natural product total synthesis and mechanism of action, new synthetic methodology, medicinal chemistry, and chemical biology Scripps Original View

Synthetic Protein Chemistry
Philip E. Dawson, Associate Professor of Chemistry Associate Dean of Graduate and Postdoctoral Studies The Scripps Research Institute, 1997-present Ph. D. Protein Chemistry, The Scripps Research Institute, 1996 Postdoctoral Associate, California Institute of Technology, 1997 Faculty, The Scripps Research Institute, 1997- Alfred P. Sloan Fellow, Elected Councilor, American Peptide Society, Vincent du Vigneaud Award for outstanding achievement in peptide research, 2010 Gold Medal of the Max Bergmann Kreis, 2011 Chairman, American Peptide Symposium, 2011 Elected Chairman, Gordon Research Conference, 2016 >75 Invited lectures 4 Scientific Advisory Boards 4 Journal Editorial Boards >100 Peer Reviewed Publications >1,400 citations (ISI) for publication on Native Chemical Ligation >30 graduate and postdoctoral students Development of new methods for the chemical synthesis of proteins and chemoselective protein bioconjugation with applications focused on the development of antiviral agents and vaccines; biological imaging with nanoparticles and basic research into protein folding and catalysis.

Catalysis and Organic Synthesis
Valery V. Fokin, Associate Professor The Scripps Research Institute, 2000-present Ph.D. in Chemistry 1998, University of Southern California Among Top 10 Most Cited Chemists (ISI/Thomson, 2011) Society of Synthetic Organic Chemistry of Japan Award (2008) Pfizer Young Investigator Award (2002) 6 graduate students, 28 postdoctoral fellows > 100 scientific publications > 80 invited lectures Inventor on 11 U.S. patents and patent applications Scripps Original View The research in Prof. Fokin’s laboratory is centered on the discovery of new catalytic processes and chemical reactivity and on applying it to the studies of macromolecular and biological phenomena. Projects involve new reaction development, studies of the organic and organometallic mechanism, medicinal chemistry, and materials science.

Kim D. Janda. Ph. D. Ely R. Callaway Jr
Kim D. Janda. Ph.D. Ely R. Callaway Jr. Chair in Chemistry, The Skaggs Institute for Chemical Biology Director, Worm Institute for Research & Medicine (WIRM) Education: B.S., Clinical Chemistry, University of South Florida, 1980 M.S., Organic Chemistry, University of Arizona, 1983 Ph.D., Organic Chemistry, University of Arizona, 1984 NIH FIRST award 1990 A.P. Sloan Fellowship 1993 A.C. Cope Scholar Award 1999 J. Clarence Karcher Lecture 2000 Outstanding Alumnus in Chemistry USF 2001 Shire BioChem Lecture 2002 Fellow AAAS 2003 Office of Life Sciences Distinguished Lecture NUS 2006 Doctor of Philosophy honoris causa, U. of Helsinki 2009 Harold A. Iddles Lecture U. of New Hampshire 2010 Harvey W. McFadden Jr. Lecture U. Nebraska Medical Center Arran Thomas Amadeo Streppa Memorial Lecture Sealy Center for Vaccine Development 2012 Raymond N. Castle Plenary Lecture USF 2012 460 publications, 1 Book 340 Invited Lectures Discover magazine’s Top 100 Science Stories of 2006 Bioorganic & Medicinal Chemistry American Regional Editor PLoS ONE Associate Editor Companies Founded: CombiChem, Drug Abuse Sciences, AIPartia

Nucleic Acid Chemistry and Biochemistry
Gerald F. Joyce, Professor of Molecular Biology and Chemistry The Scripps Research Institute, 1989-present Ph.D. 1984, University of California, San Diego M.D. 1984, University of California, San Diego Postdoctoral Fellow, The Salk Institute, 1985–1989 Member, U.S. National Academy of Sciences Member, American Academy of Arts & Sciences Chair, JASON Scientific Advisory Panel for U.S. National Security U.S. National Academy of Sciences Award in Molecular Biology, 1994 Pfizer Award in Enzyme Chemistry, 1995 Herbert W. Dickerman Award, 1997 Hans Sigrist Prize, 1997 Head of Faculty in Chemical Biology, F1000, 2000–present H.C. Urey Award, 2005 Dannie Heineman Prize, 2009 Technical Advisory Council, BP, 2009–present U.S. National Academy of Sciences Miller Award, 2010 Scripps Original View 10 Ph.D. students and 28 postdoctoral fellows 150 scientific publications 12 issued U.S. patents Directed evolution of nucleic acid enzymes, synthetic biology, origins of life

Chemical Biology Michael A. Marletta, Professor of Chemistry, The Scripps Research Institute 2012-present Ph.D., Pharmaceutical Chemistry 1978, University of California, San Francisco NIH Postdoctoral Fellow, MIT, Faculty: Department of Applied Biological Sciences, MIT, Faculty: Departments of Medicinal Chemistry (Pharmacy) and Biological chemistry (Medical School), University of Michigan Investigator: HHMI, John G. Searle Chair, University of Michigan, Faculty: Departments of Chemistry and Molecular and Cell Biology, University of California, Berkeley, Aldo DeBenedictis Distinguished Professor of Chemistry, UCB, President and CEO, The Scripps Research Institute, 2012-present MacArthur Fellowship, 1995 Institute of Medicine, 1997 Harrison Howe Award, ACS, 2004 National Academy of Sciences, 2006 Repligen Award, ACS, 2007 Kaiser Award, Protein Society, 2007 Esselen Award for Chemistry in the Public Interest, ACS, 2007 Fellow, Royal Society of Chemistry 2009 >200 papers 41 Ph.D. and 35 Postdoctoral Students Editorial Board, PNAS Chemistry of novel enzyme reactions, protein structure and function

Total Synthesis of Biologically Active Natural and Designed Molecules
K.C. Nicolaou Skaggs Professor of Chemical Biology & Distinguished Professor of Chemistry Department of Chemistry Department of Chemistry & Biochemistry The Scripps Research Institute University of California, San Diego _________________________________________ Honors Fellow, American Academy of Arts and Sciences Member, National Academy of Sciences, USA Corresponding Member, Academy of Athens, Greece Member, German Academy of Sciences Leopoldina Member, American Philosophical Society Awards Benjamin Franklin Medal in Chemistry ACS Arthur C. Cope Award Tetrahedron Prize for Creativity in Organic Synthesis ACS Linus Pauling Medal 750 Publications and 5 Books 66 Patents (Issued) >450 Postdoctoral Fellows and Graduate Students Scripps Original View Total synthesis of natural products, new synthetic technologies, chemical biology, medicinal chemistry.

Molecular Recognition and Self-Assembly
Julius Rebek, Jr., Director, Skaggs Institute for Chemical Biology and Professor of Chemistry, The Scripps Research Institute, 1996-present Ph. D. Chemistry 1970, MIT; NSF Fellow Faculty: Department of Chemistry, UCLA, Faculty: Department of Chemistry, Univ. of Pittsburgh, Faculty: MIT, Camille Dreyfus Professor Alfred P. Sloan Fellow, Guggenheim Fellow, 1986 ACS A. C. Cope Scholar, 1991 American Academy of Arts and Sciences, 1993 National Academy of Science, 1994 NIH Merit Award, ACS Norris Award for Physical Organic Chemistry, 1997 Hungarian Academy of Science, 2001 ACS Breslow Award in Biomimetic Chemistry, 2004 European Academy of Science, 2005 Distinguished Scientist Award, ACS, San Diego, 2006 Fellow, Royal Society of Chemistry, 2009 Humboldt Senior Scientist Award, Germany, 2009 Honorary Doctorate, University of Bonn, 2010 Nichols Medal, ACS New York 2011 Prelog Medal, ETH Zurich, 2012 Among Top 100 Cited Chemists >50 Ph.D. and > 220 Postdoctoral co-workers 550 Publications >60 Named Lectureships Molecular self-replication, encapsulation and assembly; antidotes and sensors for nerve agents. Scripps Original View

Ed Roberts Ed Roberts is a Professor in the Department of Chemistry at the Scripps Research Institute (TSRI) where he works on translational programs in several therapeutic areas such as pain/inflammation, pervasive developmental disorders, multiple sclerosis, epilepsy, alcohol/substance abuse, depression, stress and anxiety. Much of his work revolves around the design of compounds exhibiting selective polypharmacology and allosteric modulators for peptidergic GPCRs. With 3 decades of medicinal chemistry experience, Ed has enjoyed a very successful career within the Pharmaceutical industry and has helped progress many compounds into clinical trials and beyond at Parke-Davis (now Pfizer), AstraZeneca and latterly as Senior Vice President and head of all discovery chemistry at F. Hoffmann-La Roche in Switzerland. Ed has been involved in the start-up of 3 companies, All in preclinical/clinical development for Rheumatoid Arthritis, Cancer, Multiple Sclerosis and IBD’s. Ed is a graduate of the University of Sussex, University of Newcastle upon Tyne, Columbia Business school, IMD (Lausanne) and London Business school. He was Adjunct Professor at McGill University (Montreal) and a member of the Board of Directors of Centre Recherche Calcul Applique (CERCA), Montreal. Ed is also past President of the Basler Chemishe Gasellschaft. Dr. Roberts is currently Fellow of the Royal Society of Chemistry, Fellow of the Royal Society of Medicine, Chartered Chemist, Chartered Scientist and Adjunct Professor UNE.

Floyd E. Romesberg, Associate Professor of Chemistry,
Chemical, Biological, and Biophysical Approaches to Understanding and Manipulating Evolution Floyd E. Romesberg, Associate Professor of Chemistry, The Scripps Research Institute, 1999-present Ph. D. Chemistry 1994, Cornell Univ., NIH Fellow Baxter Foundation Award, 2002 Camille Dreyfus Teacher Scholar Award, 2003 Susan B. Komen Breast Cancer Foundation Award, Discover Magazine Technology Innovation Award, 2004 NSF CAREER Award, 2004 – present Member, Institute for Defense Analysis, Defense Science Study Group, PLoS One Editorial Board, 2006 – present CPCh Current Protocols Editorial Board, 2010 – present Founder of the biotechnology companies Achaogen, Inc. and RQx Pharmaceuticals, Inc. 17 Ph.D. and 34 Postdoctoral Students >100 Publications > 80 Invited Lectures Scripps Original View Chemical biology, microbiology, molecular biology, and biophysics are used as part of an effort to expand the genetic alphabet and create a semi-synthetic organism, develop novel broad-spectrum antibiotics, and understand how the evolution of protein dynamics contributes to biological function.

New Chemical Biology from Ancient Enzymes (Aminoacyl tRNA Synthetases)
Paul Schimmel, Ernest and Jean Hahn Professor of Molecular Biology and Chemistry Ph.D. Biophysical Chemistry, MIT 1966, Postdoctoral Fellow, Stanford University Faculty: MIT Department of Biology (last position, John D. and Catherine T. MacArthur Professor of Biochemistry and Biophysics) Faculty: The Scripps Research Institute, Departments of Molecular Biology and Chemistry (current position, Ernest and Jean Hahn Professor of Molecular Biology and Chemistry) 1997-present Faculty, Visiting Professor, Institute for Advanced Study, Hong Kong University of Science and Technology 2008-present Alfred P. Sloan Fellow, Pfizer Award in Enzyme Chemistry, 1978 Elected American Academy of Arts and Sciences, 1987 Elected US National Academy of Sciences, 1990 Elected American Philosophical Society, 1999 Biophysical Society Emily M. Gray Award for Significant Contributions (co-recipient), 2000 Nucleic Acids Award, British Biochemical Society and Royal Society of Chemistry, 2004 Elected Institute of Medicine of US National Academy of Sciences, 2005 David Perlman Award, The American Chemical Society, 2005 Chinese Biopharmaceutical Association Brilliant Achievement Award, 2006 Ohio Wesleyan University Distinguished Achievement Award, 2007 Stein and Moore Award, The Protein Society, 2007 San Diego BioPharma Award, 2011 Frank H. Westheimer Medal, Harvard University, 2012 Author or co-author of over 450 scientific publications Co-author of widely used 3-volume textbook on Biophysical Chemistry Service on 11 journal editorial boards Service (including chairmanships) on 25 corporate boards for profit and non-profit enterprises Chairmanships and memberships on 33 committees for outside academic, scientific and government organizations

The Scripps Research Institute, 1999-present
Biological Chemistry Peter G. Schultz, Scripps Family Chair Professor, Department of Chemistry The Scripps Research Institute, 1999-present Ph.D., Organic Chemistry, California Institute of Technology (1984) Postdoctoral Fellow, Massachusetts Institute of Technology (1984) Faculty, University of California, Berkeley, Department of Chemistry ( ) Principal Investigator, Lawrence Berkeley Laboratory ( ) Howard Hughes Medical Investigator ( ) Founder and Director, Genomics Institute of the Novartis Research Foundation ( ) Founder and Director: Affymax Research Institute, Syrrx, Kalypsys, Phenomix, Ambrx, Ilypsa, Wildcat Discovery Technologies, Ardelyx Founder and Director, California Institute for Biomedical Research (2012-present) Scientific Advisory Board, Welch Foundation (2003-present) Alan T. Waterman Award, National Science Foundation (1998) American Chemical Society Award in Pure Chemistry (1990) College of Chemistry Teaching Award, University of California, Berkeley (1992) National Academy of Sciences, USA (1993) Wolf Prize in Chemistry (1994) Institute of Medicine of the National Academy of Sciences (1998) 2002 Paul Ehrlich-and Ludwig Darmstaedter Prize (2003) Arthur C. Cope Award, American Chemical Society (2006) Over 510 published manuscripts Approximately 350 previous predoctoral and postdoctoral trainees (~90 are university faculty throughout the world) The focus of our research is the synthesis of molecules and molecular assemblies with novel physical, chemical or biological properties and functions. We pursue a biologically inspired approach to synthesis in which the molecules and processes of living organisms are combined with the principles and tools of chemistry to create molecules with new functions difficult to generate by either approach alone. By studying the properties of the resulting molecules, new insights are gained into the molecular mechanisms of complex biological and chemical systems.

Catalysis: Biological and Abiological
K. Barry Sharpless, W.M. Keck Professor of Chemistry The Scripps Research Institute, present PhD, Stanford University (E. E. van Tamelen), 1968 postdoctoral, Stanford University (J. P. Collman), 1968 postdoctoral, Harvard University (K. Bloch), 1969 Massachusetts Institute of Technology, 1970–77, 1980–90 Arthur C. Cope Professor, 1987–90 Stanford University, 1977–80 American Academy of Arts & Sciences, 1984 National Academy of Sciences, 1985 Award for Creative Work in Organic Synthesis, 1983 Tetrahedron Prize (with Noyori), 1993 Arthur C. Cope Award, 1992 King Faisal Prize for Science, Saudi Arabia, 1995 Roger Adams Award in Organic Chemistry, 1997 Wolf Prize (with Kagan & Noyori), Weizmann Institute, 2001 Nobel Prize in Chemistry (with Knowles & Noyori), 2001 >400 Publications, 30 patents Scripps Original View Homogeneous Catalysis, Organic Synthesis, Click Chemistry, Target-templated in situ Drug Design

Complex Molecule Synthesis and Methods Development
Ryan A. Shenvi, Assistant Professor of Chemistry The Scripps Research Institute, 2010-present Ph.D. Chemistry, 2008, The Scripps Research Institute Postdoctoral Fellow, , Harvard University Development of new anti-proliferative and antimalarial chemotypes; development of new methods for C-N bond formation Boehringer-Ingelheim Young Investigator Award, 2012 Eli Lilly New Faculty Award, 2011 NIH Ruth L. Kirschstein Fellowship, 2008–2010  • Roche Excellence in Chemistry Award, 2007 • Lesly Starr Shelton Award, 2007 • NDSEG Predoctoral Fellow, TSRI, 2005–2008 Pfizer Summer Research Fellow, 2002 John and Elizabeth Holmes Teas Scholarship, 2001 William G. and Elizabeth K. Leitzell Scholarship, 2000 National Merit Corporate Scholarship, 1999 – 2003 5 Ph.D. and 3 Postdoctoral Students 16 scientific publications 2 issued U.S. patents

Structure and Dynamics of Ribonucleoprotein Assemblies
James R. Williamson, Departments of Integrated Structural and Computational Biology and Chemistry, The Scripps Research Institute, 1998-present Dean of Graduate and Postdoctoral Studies Ph. D. Chemistry, 1988, Stanford University Jane Coffin Childs Fellow Faculty, Department of Chemistry, MIT Pfizer Laubach Professorship 1991 Searle Scholar Award, 1991 Rita Allen Scholar Award 1994 Alfred P. Sloan Fellow 1995 Camille Dreyfus Teacher-Scholar Award 1995 American Academy of Arts and Sciences 2010 Founder of the biotechnology company Cassia, LLC 18 Ph.D. students 37 postdoctoral fellows > 150 publications > 300 Invited lectures Study of RNA-protein complexes using a wide variety of biophysical techniques, include X-ray crystallography, NMR spectroscopy, fluorescence spectroscopy, and Electron Microscopy. Focus on the dynamics of ribosome assembly and structures of assembly intermediates, RNA-protein complexes that regulate T-cell activation, and DEAD-box helicases involved in HIV replication

Bioorganic and Carbohydrate Chemistry
Chi-Huey Wong, Professor of Chemistry, The Scripps Research Institute, 1989-present Ph.D. Chemistry 1982, Massachusetts Institute of Technology Faculty: Department of Chemistry, Texas A&M University, Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute, 1989–2006 Professor of Chemistry, The Scripps Research Institute, 2006-present Director of the Genomics Research Center at Academia Sinica, Taipei, President, Academia Sinica, Taipei, Taiwan, 2006-present ACS Cope Scholar, 1993 ACS Claude S. Hudson Award in Carbohydrate Chemistry, 1999 Presidential Green Chemistry Challenge Award, 2000 ACS Award for Creative Work in Organic Chemistry, 2005 F. A. Cotton Medal for Excellence in Chemical Research, 2008 ACS Arthur C. Cope Award, 2012 Nikkei Asia Prize for Science, Technology and Innovation, 2012 Elected American Academy of Arts and Sciences, 1996 Elected Member of the US National Academy of Sciences, 2002 Among Top 100 Cited Chemists, H-index 93 Over 680 Publications, 100 patents and 5 Books Scripps Original View Interests are in bioorganic and synthetic chemistry and biocatalysis, including synthesis of complex carbohydrates, glycoproteins and small-molecule probes for the study of carbohydrate-mediated biological recognition, post-translational glycosylation, and drug discovery.

Nuclear Magnetic Resonance (NMR) Spectroscopy
Kurt Wüthrich is the Cecil H. and Ida M. Green Professor of Structural Biology at The Scripps Research Institute, La Jolla, CA, USA and Professor of Biophysics at the ETH Zürich, Zürich, Switzerland. His research interests are in molecular structural biology, and in structural genomics. His specialty is nuclear magnetic resonance (NMR) spectroscopy with biological macromolecules, where he contributed the NMR method of three-dimensional structure determination of proteins and nucleic acids in solution. Kurt Wüthrich’s achievements have been recognized by the Prix Louis Jeantet de Médecine, the Kyoto Prize in Advanced Technology, the Nobel Prize in Chemistry, and by a number of other awards and honorary degrees.

Regioselective and Enantioselective C-H Activation Reactions
Jin-Quan Yu, Professor of Chemistry, The Scripps Research Institute 2010-present Ph. D. Chemistry 1999, Cambridge University St John’s College Research Fellow, Cambridge University, Postdoctor: Harvard University, Royal Society University Fellowship: Cambridge University 2003 Faculty: Department of Chemistry, Brandeis University, Mukaiyama Award, Society of Organic Synthesis, Japan, 2012 ACS Cope Scholar Award, 2012 98 Publications, 6 patents C-H activation/C-C bond and C-heteroatom bond forming reactions Short synthesis of pharmaceutically interesting compounds via C-H bond disconnection; New methods for heterocycle synthesis Structural diversifications of biologically active natural products through C-H functionalization method Late-stage installation of radioactive markers for biological studies

Chemistry Faculty Florida Campus

Chemistry and Chemical Biology
Kate S. Carroll, Associate Professor of Chemistry, The Scripps Research Institute, 2010-present Damon Runyon Post Doctoral Fellow 2003, UC Berkeley Ph. D. Biochemistry 2002, Stanford University Faculty: Department of Chemistry, University of Michigan, Leukemia and Lymphoma Society Special Fellow Award, 2006 Biological Sciences Scholar Award, University of Michigan, 2006 American Heart Association Scientist Development Award, 2008 Camille Dreyfus Teacher-Scholar Award, 2010 ACS Pfizer Award in Enzyme Chemistry, 2013 Editorial Board: Journal of Biological Chemistry, FASEB Journal Board of Directors: TargAnox Biotechnology Company 6 Ph.D. and 10 Postdoctoral Students >50 Publications >75 Invited Lectures Scripps Original View Protein post-translational modifications that contribute to human health and disease with specific projects in the areas of cancer, inflammation, and bacterial infection. We use the techniques of organic synthesis, biochemistry, and chemoproteomics as tools to study and manipulate complex cellular processes.

Structural and Chemical Biology
Designer Small Molecules Targeting RNA Matthew D. Disney, Associate Professor of Chemistry, The Scripps Research Institute, 2010-present Ph. D. Chemistry 2003, University of Rochester Postdoctoral Associate MIT and ETH, Zurich Faculty: Department of Chemistry and Center of Excellence in Bioinformatics, University at Buffalo, SUNY American Chemical Society Eli Lilly Award in Biological Chemistry American Chemical Society Carbohydrate Division David Y. Gin Award University at Buffalo, Exceptional Scholar Camille & Henry Dreyfus Teacher-Scholar Award Research Corporation Cottrell Scholar Award NYSTAR James D. Watson Young Investigator Award Camille & Henry Dreyfus New Faculty Award Howard Hughes Medical Institute Research Fellow. 1997 3 Ph.D. and 11 Postdoctoral Students >60 publications >40 Invited Lectures Scripps Original View Structural and Chemical Biology of RNA

Chemistry, Biochemistry and Medicine
Thomas Kodadek, Vice-Chairman and Professor of Chemistry & Cancer Biology The Scripps Research Institute, Scripps Florida 2009-present Ph. D. Organic Chemistry 1985, Stanford University Post-doctoral: Biochemistry & Molecular Biology, , UCSF Assistant, Assoiate. and Professor of Chemistry & Biochemistry, Univ. of Texas at Austin, Professor of Internal Medicine & Molecular Biology, UT-Southwestern Medical Center, Director, Division of Translational Research, UT Southwestern Medical Center, • American Cancer Society Junior Faculty Research Award ( ) • Fellow of the AAAS (elected 1999) • NIH Director’s Pioneer Award ( ). • Founding Chief of the Editorial Board, Molecular BioSystems, Royal Society of Chemistry, • Associate Editor, Chemistry & Biology, • Editorial Board, Chemistry & Biology, 1998-Present • Editorial Board, Curr. Op. In Chemical Biology, 2000-present • Scientific Advisory Boards, Stratagene, Opko, Sigma-Aldrich, Receptors, LLC Scripps Original View Research: Dr. Kodadek’s laboratory develops chemical tools for medicine and biology. He has made fundamental contributions to our understanding of organometallic atom transfer reactions, the biochemistry of genetic recombination and transcription and to the study of protein-protein interactions His current work focuses on the discovery of serum biomarkers for the early diagnosis of disease and the development of highly selective drugs and chemical probes.

new synthetic methodology
Synthetic Methods and Natural Products Glenn C. Micalizio, Associate Professor of Chemistry, The Scripps Research Institute 2008-present • Postdoctoral Fellow 2003, Harvard University (Helen Hay Whitney Fellow) • Ph. D. Chemistry 2001, University of Michigan (American Chemical Society Division of Organic Chemistry Fellow) Faculty: Department of Chemistry, Yale University, Lilly Grantee Award, 2006 Boehringer Ingelheim New Investigator Award, 2007 American Cancer Society Research Scholar Award, 2006 Beckman Young Investigator Award, 2005 Boehringer Ingelheim Award, 2005 Lilly New Faculty Award, 2003 • Rackham Predoctoral Fellow, 2000 17 Ph.D. and 13 Postdoctoral Students > 50 Publications > 78 Invited Lectures Inventor on 2 U.S. Patents Scripps Original View Natural product total synthesis, natural product-inspired function-oriented synthesis, new synthetic methodology

Chemical and Biological Engineering
Brian M. Paegel, Assistant Professor of Chemistry & Molecular Therapeutics, The Scripps Research Institute, 2009-present Ph. D. Chemistry 2003, UC Berkeley NIH NRSA Postdoctoral Fellow, TSRI NIH Pathway to Independence Award Faculty: Department of Chemistry, 2009− NIH Director’s New Innovator Award, 2011 Lasker Lecturer, 2010 1 Ph.D. and 3 Postdoctoral Students 16 Publications 6 patents microfluidics protein evolution supramolecular chemistry high-throughput screening encoded combinatorial synthesis Scripps Original View

Organometallic Chemistry
Roy A. Periana, Professor of Chemistry, Director of Scripps Energy & Materials Center, The Scripps Research Institute, Florida, 2007 – present Ph. D. Organic Chemistry 1985, University of California, Berkley Graduate Scholastic Honor Society, University of California, Berkley, Science publications, 1993, 1998, 2003 Co-Founder and Vice President of Research, Catalytica, 1994 – 2000 Professor of Chemistry, Department of Chemistry and Loker Hydrocarbon Research Institute, University of Southern California, 2000 – 2007 Japan Society for the Promotion of Science (JSPS) Fellowship, 2007 Visiting Associate: Chemistry and Chemical Engineering, California Institute of Technology (Caltech), 2001 – present Faculty Associate: Power Environmental & Energy Research Center, California Institute of Technology, 2003 – present Co-Founder & Board Member: Qateomix, Inc., 2005 – present Management Committee, The Center for Catalytic Hydrocarbon Functionalization, 2009 – present 13 Ph.D., 6 Undergraduate, and 9 Postdoctoral Students 79 Publications 21 Patents 110 Invited Lectures Scripps Original View Synthesis, reaction mechanisms and homogeneous catalysis with a focus on developing new, low temperature, selection conversion chemistry of small molecules such as CH4, O2, H2O, CO2 and N2.

Natural Products and Medicinal Chemistry
William R. Roush, Professor of Chemistry The Scripps Research Institute, 2005-present Ph. D. Chemistry, Harvard University 1977 Faculty: Department of Chemistry, MIT, Faculty: Department of Chemistry, Indiana University, Faculty: Warner-Lambert Park Davis Professor of Chemistry, Department of Chemistry, University of Michigan, Chair, Department of Chemistry, University of Michigan, Alfred P. Sloan Fellow, Alan R. Day Award of Philadelphia Organic Chemists Club, 1994 ACS A. C. Cope Scholar, 1994 ACS Paul G. Gassman Distinguished Service Award, 2002 ACS Guenther Award in Natural Products, 2004 Fellow of the American Association for the Advancement of Science, 2006 Fellow of the American Chemical Society, 2009 80 Ph.D. (74 completed) and 82 Postdoctoral Students >300 Publications >500 Invited Lectures Scripps Original View Natural product total synthesis, development of new synthetic methodology , stereochemistry of organic reactions, structure based drug design, chemical biology and medicinal chemistry

Natural Products Chemistry
Ben Shen, Professor of Chemistry and Molecular Therapeutics The Scripps Research Institute, 2011-present Ph.D., Chemistry, 1991, Oregon State University Faculty, Department of Chemistry, UC Davis, Faculty, Department of Chemistry and Division of Pharmaceutical Sciences, UW-Madison, Searle Scholar Award, NSF CAREER Award, American Society of Pharmacognosy, Matt Suffness Award, 2000 NIH Independent Scientist Award, American Society of Pharmacognosy Jack L. Beal Award, 2002 Charles M. Johnson Distinguished Chair, UW-Madison, Fellow, American Academy of Microbiology, 2011 Fellow, American Association for the Advancement of Science, 2011 12 Ph.D. and 58 Postdoctoral Students 175 Publications 210 Invited Lectures Scripps Original View Natural product isolation and structural elucidation Natural product biosynthesis, engineering, and structural diversity Natural product mode of action and chemical biology Natural product anticancer and antiinfectious drug discovery Enzyme reaction mechanism and structural biology Metabolic pathway engineering and synthetic biology

Enzymology and Chemical Biology
Paul R. Thompson, Associate Professor of Chemistry The Scripps Research Institute, 2010-present Ph. D. Biochemistry, 2000, McMaster University, Canada Faculty: Department of Chemistry and Biochemistry, University of South Carolina, Faculty: Department of Chemistry, TSRI, 2010-present. Chair and Associate Chair, Enzymes, Coenzymes & Metabolic Pathways Gordon Research Conference 2010 South Carolina Governor’s Young Scientist Award for Excellence in Scientific Research Camille Dreyfus Teacher Scholar Award 2009 Executive Committee, Department of Chemistry and Biochemistry, University of South Carolina, 08/ /2010. American Chemical Society Division of Biological Chemistry Nominating Committee, New Investigator of the American Heart Association, 2005 Canadian Institutes for Health Research Post Doctoral Fellowship, Thomas Neilson Scholarship, McMaster University, 1996 NSERC Graduate Student Fellowship (PGS B), NSERC Graduate Student Fellowship (PGS A), Graduated Summa Cum Laude, McMaster University, 1994 11 Ph.D. and 15 Postdoctoral Students Authored >75 scientific publications Inventor on >3 issued U.S. patents Works at the interface of chemistry and biology to validate new therapeutic targets for inflammatory diseases and cancer, with an emphasis on arginine modifying enzymes.

Chemistry Faculty La Jolla Campus Scripps Original View.

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