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After removal of duplication
Article search: Database: Pubmed Keyword: (omega-3 fatty acids or HUFAs or eicosapentaenoic acid or docosahexaenoic acid or ethyl-eicosapentaenoic acid or lipoic acid or linoleic acid) AND (autism or autism spectrum disorder or ASD or Asperger or Pervasive development disorder or PPD) Limits: No Date: date available to June 21st, 2017 (n=140) Article search: Database: ScienceDirect Keyword(omega-3 fatty acids) AND (autism OR autism spectrum disorder) Filter: No Date: date available to June 21st, 2017 (n=493) Article search: Database: Cochrane Library Keyword: (omega-3 fatty acids or HUFAs or eicosapentaenoic acid or docosahexaenoic acid or ethyl-eicosapentaenoic acid or lipoic acid or linoleic acid) AND (autism or autism spectrum disorder or ASD or Asperger or Pervasive development disorder or PPD) Limits: No Date: date available to June 21st, 2017 (n=25) Article search: Database: ClinicalTrials.gov Keyword: (omega-3 fatty acids or HUFAs or eicosapentaenoic acid or docosahexaenoic acid or ethyl-eicosapentaenoic acid or lipoic acid or linoleic acid) AND (autism or autism spectrum disorder or ASD or Asperger or Pervasive development disorder or PPD) Limits: No Date: date available to June 21st, 2017 (n=9) Identification Screening After removal of duplication (n=525) Excluding articles (n=491) Figure S1 Eligibility Eligibility (n=34) Not meeting inclusion criteria (n=28) Included Figure S1 Included articles in meta-analysis (n=6)
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Figure S2 Figure supplement figure 2A funnel plot of ABC hyperactivities subscale
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Figure supplement figure 2B funnel plot of ABC lethargy subscale
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Figure supplement figure 2C funnel plot of ABC stereotypy subscale
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Figure supplement figure 2D funnel plot of ABC inappropriate speech subscale
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Figure supplement figure 2E funnel plot of ABC irritability subscale
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Figure supplement figure 2F funnel plot of clinical improvement via CGI-I measurement
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Figure supplement figure 2G funnel plot of SRS total
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Figure supplement figure 2H funnel plot of drop out rate
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Figure supplement figure 2I funnel plot of discontinue treatment due to side effect
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