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Biomass and chronic lung disease: Is the evidence good enough, and does it matter?
Peter Burney National Heart and Lung Institute Imperial College, London
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Burden of disease attributable to 20 leading risk factors in 2010, expressed as a percentage of global disability-adjusted life-years From Lim et al. Lancet 2012; 380: 2224–60
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Biomass smoke exposure and the risk of chronic obstructive pulmonary disease (COPD). [redrawn]
Redrawn from: Eisner et al. Am J Respir Crit Care Med 2010; 182:
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Biomass smoke exposure and the risk of chronic obstructive pulmonary disease (COPD). [redrawn]
Strong evidence of publication bias Highly variable results (I2>80%) Redrawn from: Eisner et al. Am J Respir Crit Care Med 2010; 182:
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Millions Dead: How Do We Know and What Does It Mean?
Methods Used in the Comparative Risk Assessment of Household Air Pollution “….strong evidence of publication bias (Egger’s test: p = 0.007); the pooled OR was 1.94 (1.62, 2.33) with substantial heterogeneity (I2 =85%)…… …….Causal inference is supported by these findings……” Smith et al. and the HAP CRA Risk Expert Group. Annu. Rev. Public Health :185–206
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Burden of Obstructive Lung Disease (BOLD) sites
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Ala Muala, et al. Acute exposure to wood smoke from incomplete combustion - indications of cytotoxicity. Particle and Fibre Toxicology (2015) 12:33
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The evidence relating to biomass and COPD is not good enough and it does matter:
Deflects attention from more important issues Leads to sub-optimal prioritisation Distorts the research agenda Leads to ineffective policies Wastes resources
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