1. A Promising Therapy for stroke
CELL THERAPY
A Promising Therapy for stroke
NIE CONG
24TH MAR. 2014

2. Two Kinds of Cells for the Therapy
Olle Lindvall, Zaal Kokaia. Stem Cell Research in Stroke: How Far From the Clinic? [J]STROKE. 2011;42:

3. Hypothesis Ⅰ
Neural stem cells would replace
lost neurons and circuits

4. Proof: Limitations: Documented synaptic integration
Dysfunction of newly formed neurons
Poor survival of the cells
Risk of tumor formation

5. Hypothesis Ⅱ potentially be induced by stimulating
Recovery after stroke could
potentially be induced by stimulating
endogenous neurogenesis

6. To stimulate the proliferation of NSCs
Background:
NSCs’ proliferation after stroke
Goal:
To stimulate the proliferation of NSCs
To keep the new neurons alive
Cells:
Hematopoietic stem cells (mesenchymal stem cells, BMSCs)
mesenchymal stem cells, MSCs

7. Non-NSCs’ Ability to Enhance Intrinsic Repair
Y. Li, J. Chen, X.G. Chen. Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery.[J] NEUROLOGY 2002;59:514–523

8. REFERENCE:
Olle Lindvall, Zaal Kokaia. Stem Cell Research in Stroke: How Far From the Clinic? [J]STROKE. 2011;42:
Y. Li, J. Chen, X.G. Chen. Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery.[J] NEUROLOGY 2002;59:514–523 .
Robin Lemmensa, Gary K. Steinberg. Stem cell therapy for acute cerebral injury: whatdo we know and what will the future bring?[J] Curr Opin Neurol 2013, 26:617–625.
Sebastian Haas, Norbert Weidner . Jurgen Winkler. Adult stem cell therapy in stroke.[J] Curr Opin Neurol 2005,18:59–64.
Cesar V. Borlongan. Cell Therapy for Stroke: Remaining Issues to Address Before Embarking on Clinical Trials.[J] Stroke. 2009;40[suppl 1]:S146-S148.)
Yuan ZJ, Li XG. Stem cell therapy for ischemic stroke. Zhongguo Zuzhi Gongcheng Yanjiu. 2013;17(45):

9. Q&A