1. Aging Systemic Milieu Impairs Outcome after Ischemic Stroke in Rats
Pan Mengxiong 1, 2 ;Wang Peng 1 ;Zheng Chengcai 1 ;Zhang Hongxia 2 ;Lin Siyang 1 ;Shao Bei 1 ;Zhuge Qichuan 1 ;Jin Kunlin 1, 2 ;
1 Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang , China ; 2 Institute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA # Current address: Department of Neurology, The First People#cod#x00027;s Hospital of Huzhou, Zhejiang , China #cod#x000A7; Current address: Department of Surgery, Children#cod#x02019;s Hospital of Zhejinag University, School of Medcine, Zhejiang , China ;
Figure 3. Old plasma administration inhibits long-term recovery after experimental stroke in young ischemic rats. A Representative images of lesion volume at low magnification view top panel and H#cod#x00026;E-stained coronal brain sections bottom panel in vehicle, young plasma and old plasma-treated young rats 15 days after stroke. B Quantitative analysis of infarct volume in vehicle, young and old plasma-treated young rats 15 days after ischemic stroke. C Sticky tape test scores in young rats at 1, 3, 7 and 15 days after treatment with vehicle, young plasma and old plasma. D Quantitative analysis of infarct volume in vehicle, young and old plasma-treated aged rats 15 days after ischemic stroke. E Sticky tape test scores in aged rats at 1, 3, 7 and 15 days after treatment with vehicle, young plasma and old plasma. Values presented as mean #cod#x000B1; SEM. #cod#x0002A; P #cod#x0003C; 0.05; #cod#x0002A;#cod#x0002A; P #cod#x0003C; 0.01, compared with vehicle-treated group. N=7-12 per group.
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