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Influence of CYP2D6 genotype on the disposition of the enantiomers of venlafaxine and its major metabolites in postmortem femoral blood  Maria Kingbäck,

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Presentation on theme: "Influence of CYP2D6 genotype on the disposition of the enantiomers of venlafaxine and its major metabolites in postmortem femoral blood  Maria Kingbäck,"— Presentation transcript:

1 Influence of CYP2D6 genotype on the disposition of the enantiomers of venlafaxine and its major metabolites in postmortem femoral blood  Maria Kingbäck, Louise Karlsson, Anna-Lena Zackrisson, Björn Carlsson, Martin Josefsson, Finn Bengtsson, Johan Ahlner, Fredrik C. Kugelberg  Forensic Science International  Volume 214, Issue 1, Pages (January 2012) DOI: /j.forsciint Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Enantiomeric (S/R) concentration ratios for venlafaxine (VEN) and its metabolites O-desmethylvenlafaxine (ODV), N-desmethylvenlafaxine (NDV) and N,O-didesmethylvenlafaxine (DDV) in femoral blood after dividing the cases into CYP2D6 genotypes (0 active genes n=6, 1 active gene n=24 and 2 active genes n=23). Values are means±SD. Forensic Science International  , DOI: ( /j.forsciint ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 Metabolite/parent drug (M/P) concentration ratios and total (S+R) concentration for venlafaxine (VEN) and its metabolites O-desmethylvenlafaxine (ODV), N-desmethylvenlafaxine (NDV) and N,O-didesmethylvenlafaxine (DDV) in femoral blood after dividing the cases into CYP2D6 genotypes (0 active genes n=6, 1 active gene n=24 and 2 active genes n=23). Values are means±SD. Forensic Science International  , DOI: ( /j.forsciint ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

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