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European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results of the treatment of skin cancer Giulia Bertino, Gregor Sersa, Francesca De Terlizzi, Antonio Occhini, Christina Caroline Plaschke, Ales Groselj, Cristobal Langdon, Juan J. Grau, James A. McCaul, Derrek Heuveling, Maja Cemazar, Primoz Strojan, Remco de Bree, C. Renè Leemans, Irene Wessel, Julie Gehl, Marco Benazzo European Journal of Cancer Volume 63, Pages (August 2016) DOI: /j.ejca Copyright © 2016 The Author(s) Terms and Conditions
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Fig. 1 Distribution of the tumour nodules according to the different anatomical subsites. European Journal of Cancer , 41-52DOI: ( /j.ejca ) Copyright © 2016 The Author(s) Terms and Conditions
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Fig. 2 Primary BCC: baseline (left), 2 months after ECT (center), and 1 year after ECT (right) (finger electrode 10 mm, local anaesthesia, i.v. bleomycin 15,000 IU/m2, 3 pulses). The patient was offered surgery and radiotherapy but refused both due to respectively cosmetical and functional outcome (surgery), and long duration treatment (radiotherapy). The patient explained that he would prefer to try ECT reserving surgery or radiotherapy for possible recurrence. European Journal of Cancer , 41-52DOI: ( /j.ejca ) Copyright © 2016 The Author(s) Terms and Conditions
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Fig. 3 Recurrent BCC: baseline (left), 2 months after ECT (center), 1 year after ECT (right) (row-needle electrode 10 mm; local anaesthesia + sedation; i.v. bleomycin 15,000 IU/m2, 4 pulses) The patient was previously submitted to surgery (three times) and refused another operation. Radiotherapy was deemed less optimal due to extension over both the nose, cheek, and up to the medial cantus (arrow). European Journal of Cancer , 41-52DOI: ( /j.ejca ) Copyright © 2016 The Author(s) Terms and Conditions
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Fig. 4 Primary SCC in a patient with concomitant lung metastases from colorectal carcinoma: baseline (left), 2 months after ECT (center), and 7 months after ECT (right) (exagonal electrode 30 mm, general anaesthesia, i.v. bleomycin 15,000 IU/m2, 6 pulses). Due to advanced stage of the patients colorectal carcinoma, life expectancy was limited and major surgery was deemed to be an unreasonable intervention for this patient, likewise a long treatment course of radiotherapy was discouraged. At the same time, the patient had symptoms and so a short intervention as ECT was chosen. European Journal of Cancer , 41-52DOI: ( /j.ejca ) Copyright © 2016 The Author(s) Terms and Conditions
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Fig. 5 Recurrent SCC: baseline (left), 2 months after ECT (center), 1 year after ECT (right) (exagonal electrode 10 mm, general anaesthesia, i.v. bleomycin 15000 IU/m2, 3 pulses) The patient was previously submitted to partial maxillectomy and refused another major operation with reconstruction. Furthermore, the patient suffered from rapidly progressing Parkinson's disease. Radiotherapy was suggested, but refused by the patient due to the long duration of treatment. Thus he preferred to try ECT. European Journal of Cancer , 41-52DOI: ( /j.ejca ) Copyright © 2016 The Author(s) Terms and Conditions
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Fig 6 EQ-5D mean values at baseline and at each follow-up visit.
European Journal of Cancer , 41-52DOI: ( /j.ejca ) Copyright © 2016 The Author(s) Terms and Conditions
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Fig. 7 QLQ-C30 mean values at baseline and at each follow-up visit.
European Journal of Cancer , 41-52DOI: ( /j.ejca ) Copyright © 2016 The Author(s) Terms and Conditions
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Fig. 8 QLQ-H&N35 mean values at baseline and at each follow-up visit.
European Journal of Cancer , 41-52DOI: ( /j.ejca ) Copyright © 2016 The Author(s) Terms and Conditions
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Fig. 9 Overall survival in total cohort and in subgroups per diagnosis. BCC = basal cell carcinoma; MM = malignant melanoma; SCC = squamous cell carcinoma; OTH = other histologies. European Journal of Cancer , 41-52DOI: ( /j.ejca ) Copyright © 2016 The Author(s) Terms and Conditions
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Fig. 10 Local disease-free survival in the total cohort and in subgroups per diagnosis. BCC = basal cell carcinoma; MM = malignant melanoma; SCC = squamous cell carcinoma. European Journal of Cancer , 41-52DOI: ( /j.ejca ) Copyright © 2016 The Author(s) Terms and Conditions
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Fig. 11 Local disease-free survival in CR patients observed in the total cohort and in subgroups per diagnosis. BCC = basal cell carcinoma; MM = malignant melanoma; SCC = squamous cell carcinoma. European Journal of Cancer , 41-52DOI: ( /j.ejca ) Copyright © 2016 The Author(s) Terms and Conditions
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