1. From: Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain
Invest. Ophthalmol. Vis. Sci ;58(6):BIO52-BIO60. doi: /iovs
Figure Legend:
Examples of corneal small nerve fiber change following 28 doses of cibinetide. Small nerve fibers visualized in the sub-basal layer of the cornea using in vivo confocal microscopy (top) and GAP-43 immunoreactivity within the epidermis of biopsies of distal lower limb (bottom), exhibit increases following daily administration of 4 mg of cibinetide. The distribution of corneal nerve fibers is shown for a healthy volunteer (A), compared to that of a subject having sarcoidosis with SNFL enrolled in the current study at baseline (B) and after 28 days of cibinetide (4 mg) treatment (C). Skin biopsies immunostained for GAP-43 reveal intraepidermal nerve fibers at baseline ([D]; arrow), which become more numerous with branching following cibinetide (4 mg; [E]). *Dermal-epidermal junction. Skin biopsy scale bar: 100 μm.
Date of download: 11/1/2017
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