1. Disruptions in GI Cancers

2. Pancreatic Cancer

3. CDKN2A/p16 inactivation

4. growth inhibition

5. Hedgehog

6. growth

7. paracrine signaling

8. Colorectal Cancer

9. HNPCC

10. (post-replication) & other
DNA repair
(post-replication) & other

13. PI3 Kinase

14. protein kinase C

17. Wnt

18. Adenomatous Polyposis Coli (APC)

19. ½ life = 2 hrs
½ life = 20’
growth

20. apoptosis
wnt

21. Bottom of Crypt
Top of Crypt

22. Non-sense mutation
Polyp

23. Chromosomal instability  Aneuploidy

26. Stomach Cancer

27. (e.g., H. pylori infection, bacteria/toxins from improperly-prepared food)

28. Interstitial cells of Cajal (SMCs)

30. Liver Cancer