1. Obesity and its metabolic complications in IVF
Veronika U. Smolnikovaa, Victoria K. Gorshinovaa, Daria V. Tsvirkuna, Iuliia A. Sukhanovaa,b, Nadezhda V. Tarasovaa, Maria A. Volodinaa, Elena A. Kalininaa, Mikhail Yu. Vysokikha,b, Gennady T. Sukhikha
a Federal State Budget Institution “Research Center for Obstetrics, Gynecology and Perinatology”, Ministry of Healthcare of the Russian Federation, 4 Oparina street, Moscow, Russian Federation
b Belozerskii Institute of Physico-chemical Biology, Moscow State University, Moscow, Leninskie gory 1, , Russian Federation

2. Taking into account the data about the regulatory effect of adipokines on all levels of the reproductive system, we aim to assess proinflammatory state and its correlation with oocyte quality, fertilization rate and early embryogenesis in obese and normal weight women who underwent ovarian stimulation using IVF protocols.

3. P – level of significance
Main treatment characteristics in IVF program according to female BMI
Variable
Group 1
(BMI 18,5-24,99 kg/m2)
Group 2
(BMI 25,0-29,99 kg/m2)
Group 3
(BMI>30,0 kg/m2)
P – level of significance
Total dose of gonadotropins (IU) *
1350,0 (1175,0-1537,5) #
1350,0 (1200,0-1650,0)
1500,0 (1237,5-1875,0) #
0,023/#- р=0,019
Duration of stimulation (days)*
9,0 (8,5-10,0) #
9,0 (8,0-11,0)
10,0 (9,0-10,5)#
0,02/#- р=0,011
Number of retrieved oocytes*
7,0 (5,0-10,0)#
5,0 (3,0-9,0)
5,0 (2,0-8,5) #
0,043/#- р=0,014
Number of mature oocytes*
6,0 (4,0-8,0) #
4,0 (3,0-8,0)
3,0 (2,0-7,0) #
0,008/#- р=0,002
Dose of gonadotropins injected per oocyte retrieved*
187,5 (143,1-340,0) #
257,1 (159,4-400,0)
330,0 (173,2-662,5) #
0,009/#- р=0,004
Dose of gonadotropins injected per mature oocyte retrieved *
217,5 (159,7-412,5) #
318,8 (173,1-562,5)
431,3 (262,5-712,5) #
0,002/#- р=0,001

4. P – level of significance
Characteristics of early embryogenesis and treatment outcomes in women in the study groups
Variable
Group 1
(BMI 18,5-24,99 kg/m2)
Group 2
(BMI 25,0-29,99 kg/m2)
Group 3
(BMI>30,0 kg/m2)
P – level of significance
Number of obtained zygotes (per 1 patient) *
6 (3-7)#
4 (2-7)
3 (2-5)#
0,022/#-
р=0,006
Fertilization rate (%)**
78,1% #
76,6%
71,2% #
p =0.02
Number of embryos to transfer *
2 (2-2)
1,000
Clinical pregnancy rate**
43,1% (31)
30,8% (12)
28,6% (14)
0,202
Implantation rate **
30,2%#
20,8%
15,9%#
0,037//#-
р=0,016
Live birth rate**
30,6% (22)
23,1% (9)
16,3% (8)
0,056
Number of cycles in which embryo
cryopreservation was performed **
41% (16)
0,249

5. Morphological quality of embryos on day 5 of cultivation among study groups

6. Correlations of adipokine levels in blood plasma with BMI.

7. Morphological evaluation of 5th day embryos and level of adipokines in the blood plasma
р=0,001
p = 0.002
р=0,007
р=0,015

8. BMI=28,5 kg/m2

9. William Howard Taft weighed more than 350 pounds
William Howard Taft weighed more than 350 pounds. After he left office as President, Yale offered him a Chair of Law. Mr. Taft replied that considering his size, it would be more appropriate to offer him a Sofa of Law.