1. TETANUS

2. MCQ
A 39-years-old lady is brought to ER with clinical diagnosis of tetanus after a penetrating wound sole 15 days back. Regarding management of tetanus, what should be line of action?
Inquire about her immunization status of tetanus
Give tetanus toxoid irrespective of her immune status
Give her TIG as a management protocol
Reassure the relative as she does not need any immunization at present

3. Causative agent Clostridium tetani
Round terminal spores give cells a “drumstick” or “tennis racket” appearance L.

4. Morphology & Physiology
Relatively large, Gram-positive, rod-shaped bacteria
Spore-forming, anaerobic.
Found in soil, and in the intestinal tracts and feces of various animals.
Most clostridia will not grow under aerobic conditions and vegetative cells are killed by exposure to O2, but their spores are able to survive long periods of exposure to air.

5. Spores are very resistant to
Reservoir
The organism is sensitive to heat and cannot survive in the presence of oxygen.
Spores are very resistant to
heat
radiation
chemicals
drying
pores can survive for a long time in environment---100yrs possibly!

6. Virulence & Pathogenicity
Infection :by the production of a potent protein toxin
tetanus toxin or tetanospasmin

7. Tetanus toxin
Produced when spores germinate and vegetative cells grow after gaining access to wounds. The organism multiplies locally and symptoms appear remote from the infection site.
One of the three most poisonous substances known on a weight basis, the other two being the toxins of botulism and diphtheria.
Because the toxin has a specific affinity for nervous tissue, it is referred to as a neurotoxin.

8. when the oxygen levels of the surrounding tissue is sufficiently low, the implanted C. tetani spore then germinates into a new, active vegetative cell that grows and multiplies and most importantly produces tetanus toxin
Tetanospasmin is an extremely lethal neurotoxin
Induces spastic paralysis
by inhibiting release of inhibitory neurotransmitters

9. tetanospasmin at the wound site, the toxin starts to migrate along nerves (peripheral motor nerve ending) where it blocks the release of inhibitory neurotransmitters
The anterior horn cell are affected after the exotoxin has passed into the blood stream
As a consequence of too much “activator transmitters”, muscles are OVERstimulated to repeatedly contract—called spastic paralysis

10. Mechanism of Action of Tetanus Toxin

12. Symptoms
The first muscles affected by tetanus are controlled by cranial nerves
Facial and jaw muscle first affected resulting in trismus. stiffness of jaw (also called lockjaw )
Eye muscles (cranial nerves III, IV) rarely are involved
if the muscle spasms affect the larynx or chest wall, they may cause asphyxiation
stiffness of abdominal ,back muscles, extremities may become so violent and strong contracted , that bone fractures may occur

13. The affected individual is conscious throughout the illness, but cannot stop these contractions
Feature of sympathetic over activity (restlessness, agitated,sweating,labile hypo and hypertension,tachycardia)
Fever is usually absent

14. Risus Sardonicus in Tetanus Patient

15. The back muscles are more powerful, thus creating the arc backward
“Oposthotonus” by Sir  Charles Bell, 1809.
Baby has neonatal tetanus with complete rigidity

16. CEPHALIC TETANUS : A Rare Form of Localized Tetanus Courtesy : Google image on tetanus)

17. Newborn showing risus sardonicus and generalized spasticity

20. Most common types: Generalized tetanus
descending pattern: lockjaw  stiffness of neck  difficulty swallowing  rigidity of abdominal and back muscles.
Spasms continue for 3-4 weeks, and recovery can last for months
Neonatal tetanus:
Form of generalized tetanus that occurs in newborn infants born without protective passive immunity because the mother is not immune.
Usually occurs through infection of the unhealed umbilical stump, particularly when the stump is cut with an unsterile instrument.

21. : Types of tetanus Uncommon types:
Incubation period: 3-21 days, average 8 days.
Uncommon types:
Local tetanus: persistent muscle contractions in the same anatomic area as the injury, which will however subside after many weeks; very rarely fatal; milder than generalized tetanus, although it could precede it.
Cephalic tetanus: occurs with ear infections or following injuries of the head; facial muscles contractions.

22. Death
may occur from tetanus, often from cardiac (heart) and respiratory (lung) effects or secondary complications from the infection

23. diagnosis The diagnosis of tetanus is based on clinical findings
although a characteristic electromyogram is suggestive.
Diagnostic studies generally are of little value, as cultures of the wound site are negative for C. tetani two-thirds of the time.
When the culture is positive, it confirms the diagnosis of tetanus

24. Diagnosis unlikely to be tetanus
Serum tetanus antitoxin once it is detected ---this protective, and make diagnosis of Tetanus unlikely
If patient history of complete vaccination and appropriate booster make diagnosis unlikely.

25. Treatment
If treatment is not sought early, the disease is often fatal.
Despite antibiotic had unproven value,however it can eradicate the vegetative cell.
penicillin10-12 millon i.v
metronidazol(500 mg 4X daily) to eradicate vegetative organisms in the wound and prevent further toxin production.
The toxin is neutralized with shots of tetanus immune globulin, TIG,which bind unbounded toxin.
Due to the extreme potency of the toxin, immunity does not result after the active tetanus.

26. What else can be done?
Remove and destroy the source of the toxin through surgical exploration and cleaning of the wound (debridement).
Bed rest with a non stimulating environment (dim light, reduced noise, and stable temperature) may be recommended.
Sedation may be necessary to keep the affected person calm. relax the muscles and relieve pain.
Respiratory support with oxygen, endotracheal tube, and mechanical ventilation may be necessary.

27. Method of prevention - immunization
A person recovering from tetanus should begin active immunization with tetanus toxoid (Td) during convalescence.
The tetanus toxoid is a formalin-inactivated toxin, with an efficiency of approx. 100%.
Because the antitoxin levels decrease over time, booster immunization shots are needed every 10 years.