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Neutrophil Activation Occurs in the Lower-limbs of Patients Undergoing Elective Repair of Abdominal Aortic Aneurysm  M.G.A. Norwood, T. Horsburgh, M.J.

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Presentation on theme: "Neutrophil Activation Occurs in the Lower-limbs of Patients Undergoing Elective Repair of Abdominal Aortic Aneurysm  M.G.A. Norwood, T. Horsburgh, M.J."— Presentation transcript:

1 Neutrophil Activation Occurs in the Lower-limbs of Patients Undergoing Elective Repair of Abdominal Aortic Aneurysm  M.G.A. Norwood, T. Horsburgh, M.J. Bown, R.D. Sayers  European Journal of Vascular and Endovascular Surgery  Volume 29, Issue 4, Pages (April 2005) DOI: /j.ejvs Copyright © 2005 Elsevier Ltd Terms and Conditions

2 Fig. 1 Graph displaying the change in the mean neutrophil count (NC) for AAA patients, during the four stages, at each location (systemic, femoral vein (FV) and portal vein (PV)). European Journal of Vascular and Endovascular Surgery  , DOI: ( /j.ejvs ) Copyright © 2005 Elsevier Ltd Terms and Conditions

3 Fig. 2 Graphical display of the mean CD11b molecular equivalents (ME) value minus the molecular equivalents value of the isotype control (ITC) for AAA patients (n=10). European Journal of Vascular and Endovascular Surgery  , DOI: ( /j.ejvs ) Copyright © 2005 Elsevier Ltd Terms and Conditions

4 Fig. 3 Graphical display of the change from baseline values of the mean CD11b molecular equivalents (ME) value minus the molecular equivalents value of the isotype control (ITC) for AAA patients (n=10). Femoral vein neutrophil CD11b expression was significantly higher than that of the portal vein prior to clamping (P=0.006, 95% Cl for the difference 1631 to 8478), during ischaemia (P=0.001, 95% CI for the difference 2870 to 9411) and reperfusion (P=0.001, 95% CI for the difference 3337 to 10034). The femoral vein neutrophil CD11b expression was also significantly higher than the systemic neutrophil CD11b expression during ischaemia (P=0.017, 95% CI for the difference 813 to 7355) and reperfusion (P=0.013, 95% CI for the difference 1021 to 7718). European Journal of Vascular and Endovascular Surgery  , DOI: ( /j.ejvs ) Copyright © 2005 Elsevier Ltd Terms and Conditions

5 Fig. 4 Graphical display of the mean CD11b-ITC values for all patients (n=6), for blood samples taken from the systemic circulation and femoral vein (FV). The centre points represent the mean values and the whiskers represent the 95% confidence intervals (95% CI). European Journal of Vascular and Endovascular Surgery  , DOI: ( /j.ejvs ) Copyright © 2005 Elsevier Ltd Terms and Conditions

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