1. A comparison of acute insulin responses to 5 g i. v
A comparison of acute insulin responses to 5 g i.v. arginine (mean: 2- to 5-min increments) at five matched glucose levels in eight patients with type 2 diabetes mellitus and in eight controls of similar age and body weight. The slope of potentiation is the linear portion of the relation between plasma glucose (100 to 250 mg/dL) and the acute insulin response. It is much flatter in the diabetic group. The maximal insulin response, a measure of β-cell secretory capacity, is the response at a glucose concentration greater than 450 mg/dL. It is also much lower in the diabetic group. The half-maximal glucose level, a measure of β-cell sensitivity to glucose, is between 150 and 200 mg/dL and is unchanged in the diabetic group. (Reproduced from Ward et al. 48 Used with permission.)
Source: β-Cell Dysfunction in Type 2 Diabetes: Pathophysiological and Genetic Bases, The Online Metabolic and Molecular Bases of Inherited Disease
Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: November 03, 2017
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