1. PARP-1 Inhibition Rescues Short Lifespan in Hyperglycemic C
PARP-1 Inhibition Rescues Short Lifespan in Hyperglycemic C. Elegans And Improves GLP-1 Secretion in Human Cells
Xia Qianghua 1 ;Lu Sumei 1 ;Ostrovsky Julian 1 ;E. McCormack Shana 2, 3, 4 ;J. Falk Marni 1, 3 ;F. A. Grant Struan 1, 2, 3, 4 ;
1 Division of Human Genetics, The Children#cod#x02019;s Hospital of Philadelphia, Philadelphia, PA 19104, USA ; 2 Division of Endocrinology and Diabetes, The Children#cod#x02019;s Hospital of Philadelphia, Philadelphia, PA 19104, USA ; 3 Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA ; 4 Institute of Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA ;
Figure 2. The lifespan-shortening effects of high glucose reduced by Olaparib treatment. A Determination of lifespan for N2 worms exposed to 16 mM glucose together with 100 uM or 0 #cod#x000B5;M Olaparib P #cod#x0003C;0.0001, log-rank test, n=100; B Determination of lifespan for N2 worms exposed to 25 mM glucose together with 100 uM or 0 #cod#x000B5;M Olaparib P #cod#x0003C;0.05, log-rank test, n=100.
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