1. RhoGEFs activate a Rho protein GTPase by catalyzing the exchange of GDP for GTP. A variety of stimuli lead to the activation of Rho protein family members via RhoGEFs, including the p21 GTPase Ras, receptor protein tyrosine kinases, and G protein-coupled receptors.28 Activated Rho leads to modified cell morphology by a reorganization of the actin cytoskeleton, a modulation of gene transcription by the activation of MAPK cascade, and the sequential activation of other Rho family member proteins. RhoGAP facilitates the hydrolysis of GTP and Rho protein inactivation. (From Gorski.5 Used with permission of Humana Press.)
Source: Aarskog-Scott Syndrome, The Online Metabolic and Molecular Bases of Inherited Disease
Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: November 03, 2017
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