1. Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology
Added prognostic value of left ventricular shape by gated SPECT imaging in patients with suspected coronary artery disease and normal myocardial perfusion
Valeria Gaudieri,a Carmela Nappi,b Wanda Acampa,a,b Emilia Zampella,b Roberta Assante,b Teresa Mannarino,b Andrea Genova,b Giovanni De Simini,b Guido Germano,c,d Mario Petretta,e and Alberto Cuocolob
a Institute of Biostructure and Bioimaging, National Council of Research, Naples, Italy
b Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy
c Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA
d David Geffen School of Medicine, UCLA, Los Angeles, CA
e Department of Translational Medical Sciences, University Federico II, Naples, Italy
Copyright American Society of Nuclear Cardiology

2. Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology
BACKGROUND
Change in cardiac size, shape and function determined by left ventricular (LV) remodeling is associated with adverse cardiovascular events
Early identification of LV remodeling might be of clinical value for risk stratification of patients with suspected coronary artery disease (CAD)
Quantitative indexes of 3-dimensional LV geometry, such as the LV shape index (SI), can be obtained automatically by gated single- photon emission computed tomography (SPECT) program
We assessed the prognostic value of LVSI in patients with suspected CAD and normal myocardial perfusion imaging
Copyright American Society of Nuclear Cardiology

3. METHODS Study type: prognostic
Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology
METHODS
Study type: prognostic
Study population: 674 with suspected CAD, normal myocardial perfusion and normal LV ejection fraction on stress gated SPECT imaging
Study variables: demographic and clinical data, coronary risk factors, stress imaging data
Study endpoints: major cardiovascular events
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4. Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology
RESULTS
P<.001
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5. Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology
RESULTS
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6. Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology
CONCLUSIONS
Age, diabetes and end-systolic LVSI are independent predictors of cardiac events during follow-up in patients with normal stress myocardial perfusion imaging
In these patients, LVSI provides additional prognostic information over age and diabetes
The evaluation of LVSI may identify patients with early stage LV remodeling and at higher risk of adverse cardiac events, even in presence of normal myocardial perfusion
Copyright American Society of Nuclear Cardiology