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signal transduction Cell-cell contact via gap junctions or plasmodesmata; signal molecule passes between cells Cell-cell recognition molecule binds to specific receptor; “receptor-ligand interaction”
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When the ligand binds, other molecules are
produced within the cell “second messengers” relay the signal from interior of cell May trigger cell activity and/or gene expression
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Things that can trigger cell signaling
G-protein-linked receptors tyrosine kinase receptors ion-channels
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Many different types of G proteins can interact
with different cellular proteins Vision Smell Acetylcholine receptors: one “family” are ion channels (contraction), another are G protein receptors (relaxation) Developmental pathways What does G protein activation accomplish? Activation of second messenger system cAMP calcium Levels are elevated
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Several families of tyrosine kinases
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Na channel
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Photoreceptor – rods and cone
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Taste Five different groups: Sweet Salty Bitter Sour Umami The different tastes can be caused by ion channels, receptor proteins and other signal pathways
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Use your receptors to smell and taste things!
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