1. ILOs of the second lecture
-What is the pathogenesis of autoimmune diseases?
-What is systemic lupus erythematosus?
-What is the clinical features of SLE?
-What are the laboratory investigations of SLE?

2. Autoimmune Diseases

3. AUTOIMMUNE DISEASES Immune reaction self antigen disease
Organ specific
Graves disease
Autoimmune hemolytic anemia
Systemic
Systemic lupus erythromatosus
Rheumatoid arthritis
Nbn

4. MECHANISMIS of AUTOIMMUNE DISEASES
Autoimmunity loss of self tolerance
Infection or injurious agent
Genetic
Mechanisms of self tolerance
Peripheral tolerance
Anergy BY:
- Regulatory T cells
- Apoptosis
Central tolerance
T cell thymus
B cell bone marrow

6. SYSTEMIC LUPUS ERYTHROMATOSUS
Systemic autoimmune disease
female, remission and relapse
Any organ affection
Autoantibodies(antinuclear antibodies) and decreased clearance of apoptotic antibodies forming immune complex leading to hypersensivity reaction type III
Break of self tolerance inherited
enviromental factors

7. Pathological features
Renal affection
Acute necrotizing vasculitis
Skin invovement (malar rash)
Joint affection
CNS involvement
splenomegaly
Serofibrinous pericarditis and pleurisy
Heart involvement

8. SLE: Malar Rash

9. SLE: vasculitis

10. Spleen: Periarteriolar fibrosis (onion skinning)

11. Clinical manifestation Laboratory investigations
Diagnosis
Clinical manifestation
Laboratory investigations
+ve Serum ANA
Urine analysis
Renal biopsy
Serum complement