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Renske W. B. Bottema, MD, Marjan Kerkhof, MD, PhD, Naomi E

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Presentation on theme: "Renske W. B. Bottema, MD, Marjan Kerkhof, MD, PhD, Naomi E"— Presentation transcript:

1 Gene-gene interaction in regulatory T–cell function in atopy and asthma development in childhood 
Renske W.B. Bottema, MD, Marjan Kerkhof, MD, PhD, Naomi E. Reijmerink, MD, Carel Thijs, MD, PhD, Henriette A. Smit, PhD, Constant P. van Schayck, PhD, Bert Brunekreef, PhD, Antoon J. van Oosterhout, PhD, Dirkje S. Postma, MD, PhD, Gerard H. Koppelman, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 126, Issue 2, Pages e10 (August 2010) DOI: /j.jaci Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Hypothetical scheme of genes involved in the Treg pathway. Subsets of Treg cells with distinct phenotypes and mechanisms of action include the naturally occurring, thymus-selected Treg cells and the inducible and adaptive Treg cells. T-naive, Undifferentiated T lymphocyte. Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Logistic regression of 2 locus models identified by MDR. aP value for interaction. bTGFBR2 rs , A = genotypes CA and AA. cFOXP3 rs , T = genotypes CT and TT. dIL6 rs , G = genotypes AG and GG. eTGFBR2 rs , A = genotypes AA and AG. fTGFB1 rs , T = genotypes CT and TT. gIL6R rs , C = genotypes CT and CC. Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Consistent direction and significance of interaction between TGFBR2 and FOXP3 in boys and girls separately, and in each cohort. aP value for interaction. bTGFBR2 rs , A = genotypes CA and AA. cFOXP3 rs , T = genotypes CT and TT. Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Interaction between TGFBR2 rs and FOXP3 rs in asthma (A) and doctor's diagnosis of asthma (B). aP value for interaction. bTGFBR2 rs , A = genotypes CA and AA. cFOXP3 rs , T = genotypes CT and TT. Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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