1. Connecting the Sections and Incorporating Feedback
Edit three times!!

2. 1. Connections between the Sections
Specific Aims Page Includes
Why work is in top 10% of importance
How work will impact human health
Hypothesis
Aims
Significance: Background, Importance, Impact
Innovation: Why approach is novel, new technology or approach, novel hypothesis

3. Approach: Introduction
Tie aims to hypothesis and significance, present specific background
Can treat each aim separately with strategy, techniques and preliminary data
Or present the overall strategy first, common methods for all aims and preliminary data that apply to all aims

4. Experimental Plan
Have you explained why aim requires specific preliminary data presented?
Have you described what you expect?
Have you seriously identified outcomes that are contrary to your expectations and alternative approaches?
Have you stated how your results will fulfill the promise of your significance.

5. 2. Modify in Response to Critiques
Clarify
Simplify
Cut

6. 3. Provide 5 Critiques for Reviewers
1. Significance: why important
2. Investigator: all skills needed or appropriate collaborators, good publication record
3. Innovation: what’s new, why now?
4. Approach: strategy, methods, analyses, ability to identify and resolve challenges, no fatal flaws, human protections, expectations
5. Environment: resources, institutional support, equipment, patient populations