1. Illuminating New Targets for Pain Treatment
Joshua Havelin
GSBSE Annual Meeting
September 17, 2016
Pecha Kucha Style Talk
Neuroscience

4. The clay tablets of the Sumerians contain the earliest written reference to the cultivation of opium.
5000 BC
1500
800
Ancient Greeks employed opium for medicinal and recreational purposes
400 80 CE
1660
Thomas Sydenham
Popularized Laudanum as effective pain relief treatment.
1804
Freidrich Serturner creates morphium
1838
1890s
Researchers at Bayer synthesized heroin.
The Ebers Papyrus, an Egyptian medical text, contains references to willow’s pain and fever-reducing qualities.
Hippocrates used powder made from bark and leaves of willow trees to provide pain relief, including headaches
Dioscorides compiled 5 volume collection of cures that includes willow bark.
Pharmacopeia-circulated in Latin, Greek, and Arabic
Raffaele Piria extracts potent acid form of active ingredients of willow bark
Researchers at Bayer purified a form of salicylic acid out of coal tar waste with fewer side effects than the willow bark extract and successfully marketed as Aspirin.
Aspirin
Opiates

5. Aspirin
Opiates
In developing and using medications to treat pain, we need to keep in mind our therapeutic goal of returning …
May depend on population:
TRPV1 story
NGF
Cancer patients-RTX

10. Breakthrough Pain
Pain Relief

11. Movement Paired Chamber Nerve Block Paired Chamber
Sham
Cancer
Movement Paired Chamber
-400
-300
-200
-100 **
Morphine
Placebo
Sham
Cancer
Nerve Block Paired Chamber
-200
200
400
Difference Score (s)
(Test-Baseline)
Morphine
Placebo *

12. CPA Chamber Control Ablation-nonpept. IB4-SAP Ablation-pept. Capsaicin
TRPV1
Pept
Nonpept
IB4
CPA Chamber
Pairing
Chamber 1
Unpaired
(Neutral)
Pairing
Chamber 2

13. Day 14
Day 7

14. Extracellular
Intracellular
Membrane Potential
Time >

16. TRPV1
IB4
MrgD

17. Neuroscience
Neuroscience