1. Oxidative Phosphorylation
Chapter 11
Oxidative Phosphorylation

2. 11.1 The Chemiosmotic Theory, Part 1
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3. 11.1 The Chemiosmotic Theory, Part 2
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4. Copyright © 2017 W. W. Norton & Company
Proton Flow
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5. Electron Transport System (Chain)
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6. Copyright © 2017 W. W. Norton & Company
Proton Circuit
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7. Energy Transformations in Oxidative Phosphorylation
View the Energy Transformations in Oxidative Phosphorylation animation
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8. Proton Uncoupling Effects
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9. Mitochondrial Structure
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10. Protein Components of the Electron Transport System
Complex
Protein
Complex I
NADH – ubiquinone oxidoreductase
Complex II
Succinate dehydrogenase
Complex III
Ubiquinone-cytochrome c oxidoreductase
Complex IV
Cytochrome oxidase
Complex V
ATP synthase complex
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11. Electron Transport System
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12. 11.2 Mitochondrial Electron Transport System – 1
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13. 11.2 Mitochondrial Electron Transport System – 2
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14. Electron Transport System Inhibitors
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15. Redox Potentials and the Electron Transport System
Electron carriers
Standard Reduction Potentials in Volts
Positive NAD plus positive 1 Hydrogen ion plus 2 electrons yields NADH
Negative 0.32
Complex 1 left parenthesis NADH-ubiquinone oxidoreductase right parenthesis: Iron-Sulfur left parenthesis N-1b right parenthesis
Negative 0.25
Complex 1 left parenthesis NADH-ubiquinone oxidoreductase right parenthesis:
Iron-Sulfur left parenthesis N-3,4 right parenthesis
Negative 0.24
Complex 1 left parenthesis NADH-ubiquinone oxidoreductase right parenthesis: Iron-Sulfur left parenthesis N-5.6 right parenthesis
Negative 0.27
Complex 2 left parenthesis succinate dehydrogenase right parenthesis: FAD plus 2 positive 1 Hydrogen ion plus 2 electrons yields FADH 2 left parenthesis enzyme bound right parenthesis
Negative 0.04
Complex 2 left parenthesis succinate dehydrogenase right parenthesis: Iron-Sulfur left parenthesis S-1 right parenthesis
Negative 0.03
Complex 2 left parenthesis succinate dehydrogenase right parenthesis: Cytochrome b 560
Negative 0.08
Complex 2 left parenthesis succinate dehydrogenase right parenthesis: Coenzyme Q plus 2 positive 1 Hydrogen ion plus 2 electrons
Positive 0.04
Complex 3 left parenthesis ubiquinone-cytochrome c oxidoreductase right parenthesis: Cytochrome b H
Positive 0.03
Complex 3 left parenthesis ubiquinone-cytochrome c oxidoreductase right parenthesis: Cytochrome b L
Complex 3 left parenthesis ubiquinone-cytochrome c oxidoreductase right parenthesis: Iron-Sulfur
Positive 0.28
Complex 3 left parenthesis ubiquinone-cytochrome c oxidoreductase right parenthesis: Cytochrome c 1
Positive 0.21
Complex 3 left parenthesis ubiquinone-cytochrome c oxidoreductase right parenthesis: Cytochrome c left parenthesis Upper C-y-t c right parenthesis
Positive 0.23
Complex 4 left parenthesis cytochrome c oxidase right parenthesis: Cytochrome a
Complex 4 left parenthesis cytochrome c oxidase right parenthesis: Copper A
Positive 0.24
Complex 4 left parenthesis cytochrome c oxidase right parenthesis: Cytochrome a 3
Positive 0.38
Complex 4 left parenthesis cytochrome c oxidase right parenthesis: One-half Upper O 2 plus 2 positive 1 Hydrogen ions yields Upper H 2 Upper O
Positive 0.82
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16. Redox Loops and Proton Pumps
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17. Copyright © 2017 W. W. Norton & Company
Complex I
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18. Copyright © 2017 W. W. Norton & Company
Complex I Structure
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19. Copyright © 2017 W. W. Norton & Company
FMN Reactions
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Coenzyme Q Function
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21. Copyright © 2017 W. W. Norton & Company
Coenzyme Q Reduction
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22. Copyright © 2017 W. W. Norton & Company
Complex II
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23. Copyright © 2017 W. W. Norton & Company
Complex III
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24. Copyright © 2017 W. W. Norton & Company
Q Cycle
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25. Cytochrome Structures
Figure Cytochrome proteins are classified as type a, type b, and type c according to the type of heme they contain. The heme group of cytochrome c is covalently linked to the protein through thiol groups from cysteine residues, whereas the type a heme has a long hydrophobic tail.
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26. Copyright © 2017 W. W. Norton & Company
Complex IV
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27. Bioenergetics of the Proton-Motive Force
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28. 11.3 Structure and Function of the ATP Synthase Complex
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29. Detailed Structure of ATP Synthase Complex
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30. ATP Synthase View the ATP Synthase animation
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31. Conformational Changes in ATP Synthase
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32. Binding Changes during ATP Synthesis in ATP Synthase
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33. Experiment Showing ATP Synthase Is a Molecular Motor
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