1. Introduction to Immunohematology
Lesson 4-5
Introduction to Immunohematology

2. Immunohematology Study of human blood groups Blood bank department
Donor blood and blood transfusions
Tissue typing
Forensic studies
Genetic studies
Paternity tests
See Table 4-7

3. History of Transfusion Medicine
William Harvey, 1628
James Blundell, 1818
Karl Landsteiner, 1900, 1930
First hospital blood bank, 1937
Improvements after WW II

4. History of Transfusion Medicine
Dramatic advancements from 1950s–1980s
AIDS
Discovered in 1980s
Caused major changes in blood donation and transfusion practices

5. Standards and Regulation
Food and Drug Administration (FDA)
Regulates
American Association of Blood Banks (AABB)
Sets standards
Accredits

6. Donor Blood Donor requirements Patient questionnaire Patient physical
See Tables 4-8 and 4-9

7. Donor Blood Donor blood collection Maintain sterility 450 mL
CPDA: anticoagulant plus nutrients
Apheresis

8. Donor Blood Processing donor blood ABO and Rh typing Antibody screen
Tests for infectious agents
See Table 4-10

9. Donor Blood Components Red blood cells Platelets
Plasma, fresh frozen plasma (FFP)

10. Storage of Donor Blood

11. Synthetic Blood Trauma victims Perfluorochemicals
Cell-free stable hemoglobin

12. Blood Bank Procedures Most tests based on agglutination Safety
ABO grouping
Rh typing
Compatibility testing
Tests for unusual antibodies
Safety
Quality assessment
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