1. Mash1-dependent Notch Signaling Pathway Regulates GABAergic Neuron-Like Differentiation from Bone Marrow-Derived Mesenchymal Stem Cells
Qianfa Long 1, 2 ;Qiang Luo a ;Kai Wang 3 ;Adrian Bates 2, 4 ;Ashok K. Shetty 2, 4 ;
1 Department of Neurosurgery, Xi#cod#x02019;an Central Hospital, Xi#cod#x02019;an Jiao Tong University School of Medicine, Xi#cod#x02019;an , China ; 2 Institute for Regenerative Medicine, Texas A#cod#x00026;M Health Science Center College of Medicine at Scott #cod#x00026; White, Temple and College Station, Texas, 76502, USA ; 3 Department of Neurosurgery, Qingdao 401 Hospital of PLA, Qingdao , China ; 4 Research Service, Olin E. Teague Veterans#cod#x02019; Medical Center, CTVHCS, Temple, Texas, USA ;
Figure 3. RNA level of Notch signaling and GABA-ergic gene expression in different cell samples A Notch signaling gene expression in DAPT+ BMSCs. B Following induction through the cocktail conditioned medium, RNA levels are shown for the neuronal and GABAergic differentiation of the DAPT+ BMSCs. C Notch signaling gene expression in genetically engineered BMSCs. D RNA levels are shown for genetically engineered BMSCs induced by the cocktail conditioned medium. #cod#x0002A; P = 0.027, #cod#x0003C; 0.05, #cod#x0002A;#cod#x0002A; P = , #cod#x0003C; 0.01, #cod#x0002A;#cod#x0002A;#cod#x0002A; P = 0.036, #cod#x0003C; 0.05, #cod#x0002A;#cod#x0002A;#cod#x0002A;#cod#x0002A; P = E-06, #cod#x0003C; 0.01.
Aging and Disease,null,8(3), Doi: /AD