1. Infectious Disease: A New Challenge for Biomedical Informatics
September 21, 2007
Cold Spring Harbor Laboratory
Supported by: The Burroughs Wellcome Fund

2. Workshop on Infectious Disease Ontology
September 19 – 20, 2007
Cold Spring Harbor Laboratory
Supported by the Burroughs Wellcome Fund

3. Purpose of Infectious Disease Ontology (IDO)
Integration of infectious disease relevant data and information
Sequence and protein data for various pathogens
Case report data for patients
Clinical trial data
Epidemiological Data
Basic biomedical, clinical care, and public health data

4. Scope of IDO
What content is needed to adequately cover the infectious domain?
Host-related terms (e.g. carrier, susceptible)
Pathogen-related terms (e.g. virulence)
Terms for the biology of disease pathogenesis (e.g. evasion of host defense)
Population-level terms (e.g. epidemic)
What should be in other ontologies?
Gene Ontology Biological Process Ontology
Clinical Trial Ontology

5. Currently Envisioned Structure of IDO
Reference ontology with terms relevant to any infectious disease
Built on OBO Foundry principles and ontologies
Disease-specific ontologies built as extensions

6. Preliminary Development Work
Generated term list
Discussed definitions
Developed hierarchy
Asserted part_of relations

7. Future Work Identify missing terms
Identify terms already in existing ontologies
Create definitions
UT Southwestern – pathogen terms
Richard Scheuerman
University of Michigan – vaccine terms
Yongqun He

8. Test IDO by developing disease-specific ontologies
U of Michigan - Brucella (Brucilosis)
Yongqun He
IMBB: Vector borne diseases (emphasis on malaria)
Christos Louis
Colorado State University: Denque fever
Saul Lozano-Fuentes
Duke: Tuberculosis
Carol Dukes-Hamilton
Cleveland Clinic – Infective Endocarditis
Sivaram Arabandi
MITRE, Mt Sinai – influenza
Joann Luciano, Stuart Sealfon

9. Getting Involved Wiki Email list
Infectious_Disease_Ontology
list
Infectious Disease Ontology Consortium